GSDMB - gasdermin B Gene

Also Known as GSDML; PP4052; GSDMB-1; PRO2521

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55876

About GSDMB

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:39,904,595-39,918,635 (from NCBI)

This gene has 15 transcripts (splice variants), 150 orthologues and 4 paralogues. Broad expression in small intestine (RPKM 18.8), duodenum (RPKM 16.9) and 17 other tissues.

Summary

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of Apoptosis in epithelial cells, and are linked to Cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Nov 2016]

GSDMB Products (10)

mRNA Protein Name
NM_001042471.2 NP_001035936.1 gasdermin-B isoform 1
NM_001165958.2 NP_001159430.1 gasdermin-B isoform 3
NM_001165959.2 NP_001159431.1 gasdermin-B isoform 4
NM_001369402.2 NP_001356331.1 gasdermin-B isoform 1
NM_001388420.1 NP_001375349.1 gasdermin-B isoform 3
NM_001388421.1 NP_001375350.1 gasdermin-B isoform 4
NM_001388422.1 NP_001375351.1 gasdermin-B isoform 1
NM_001388423.1 NP_001375352.1 gasdermin-B isoform 2
NM_001388424.1 NP_001375353.1 gasdermin-B isoform 5
NM_018530.3 NP_061000.2 gasdermin-B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cardiolipin binding IDA
IDA: Inferred from direct assay
34022140 GOA
enables phospholipid binding IDA
IDA: Inferred from direct assay
28154144 GOA
enables wide pore channel activity IDA
IDA: Inferred from direct assay
32299851 GOA
Biological Process GO Annotation Evidence References Source
involved in cytotoxic T cell pyroptotic cell death IDA
IDA: Inferred from direct assay
28154144 GOA
involved in defense response to Gram-negative bacterium IDA
IDA: Inferred from direct assay
34022140 GOA
involved in granzyme-mediated programmed cell death signaling pathway IDA
IDA: Inferred from direct assay
32299851 GOA
involved in killing by host of symbiont cells IDA
IDA: Inferred from direct assay
34022140 GOA
NOT involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
36899106 GOA
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
32299851 GOA
Cellular Component GO Annotation Evidence References Source
is active in plasma membrane IDA
IDA: Inferred from direct assay
28154144 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSDMB Protein Structure

Gasdermin

Gasdermin: Gasdermin family (4 - 377)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
Protein Preferred Names Protein Names

gasdermin-B

  • gasdermin-like protein

Related Diseases

Diseases Alias
Oral Squamous Cell Carcinoma

  • Mouth Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Mouth
Childhood-Onset Asthma

  • Childhood Asthma

  • Asthma Childhood
Chronic Asthma
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05855 GSDMB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99618 Fidasimtamab Inhibitor 95.00% Unkown