Msh4 - mutS homolog 4 Gene

Also Known as mMsh4; 4930485C04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 55993

Summary

Predicted to enable ATP-dependent activity, acting on DNA. Acts upstream of or within gamete generation; homologous chromosome pairing at meiosis; and ovarian follicle development. Located in recombination nodule and synaptonemal complex. Is expressed in several structures, including brain; gonad; heart; and thymus. Orthologous to human MSH4 (mutS homolog 4). [provided by Alliance of Genome Resources, Apr 2022]

Msh4 Products (2)

mRNA Protein Name
NM_001282054.2 NP_001268983.1 mutS protein homolog 4 isoform 2
NM_031870.4 NP_114076.2 mutS protein homolog 4 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within female gamete generation IMP
IMP: Inferred from mutant phenotype
10809667 MGI
acts upstream of or within homologous chromosome pairing at meiosis IMP
IMP: Inferred from mutant phenotype
10809667 MGI
acts upstream of or within meiotic cell cycle IDA
IDA: Inferred from direct assay
10809667 MGI
acts upstream of or within meiotic cell cycle IMP
IMP: Inferred from mutant phenotype
10809667 MGI
acts upstream of or within ovarian follicle development IMP
IMP: Inferred from mutant phenotype
10809667 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
10809667 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
30272023 MGI
located in condensed chromosome IDA
IDA: Inferred from direct assay
10809667 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
18316482 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10809667 MGI
located in recombination nodule IDA
IDA: Inferred from direct assay
27760146 MGI
located in synaptonemal complex IDA
IDA: Inferred from direct assay
10809667 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mutS protein homolog 4

  • MutS homolog 4 variant iota 1

  • MutS homolog 4 variant theta 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3662 Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Activator 99.44% Unkown
HY-P3171 Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) / Unkown
HY-RS08711 MSH4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Msh4 NCBI NCBI:4438