NXF2 - nuclear RNA export factor 2 Gene

Also Known as CT39; TAPL-2; TCP11X2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56001

About NXF2

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:102,247,167-102,326,722 (from NCBI)

This gene has 2 transcripts (splice variants), 263 orthologues and 3 paralogues. Restricted expression toward testis (RPKM 10.2).

Summary

This gene encodes a member of a family of nuclear RNA export proteins. The encoded protein is associated with the nuclear envelope and aids in the export of mRNAs. There is a closely related paralog of this gene located adjacent on chromosome X and on the opposite strand. [provided by RefSeq, Aug 2013]

NXF2 Products (1)

mRNA Protein Name
NM_022053.4 NP_071336.1 nuclear RNA export factor 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
11566096 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
part of nuclear RNA export factor complex IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NXF2 Protein Structure

Tap-RNA_bind

Tap-RNA_bind: Tap, RNA-binding (119 - 205)

NTF2

NTF2: Nuclear transport factor 2 (NTF2) domain (392 - 540)

TAP_C

TAP_C: TAP C-terminal domain (573 - 623)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 626 a.a.
Protein Preferred Names Protein Names

nuclear RNA export factor 2

  • TAP-like protein 2

NXF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NXF2B Q9GZY0 NXT2 Homo sapiens Q9NPJ8-3
Validated Y2H
32296183
Intra
NXF2B Q9GZY0 HEXB Homo sapiens P07686
Y2H Pooling
32814053
Intra
NXF2B Q9GZY0 HEXB Homo sapiens P07686
Validated Y2H
32814053
Intra
NXF2B Q9GZY0 HEXB Homo sapiens P07686
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Progesterone-Receptor Negative Breast Cancer
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09711 NXF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown