Tamalin - trafficking regulator and scaffold protein tamalin Gene

Mus musculus

Also known as Grasp

Gene ID: 56149 | Gene type: protein coding

About Tamalin

Summary

Predicted to enable PDZ domain binding activity; identical protein binding activity; and small GTPase binding activity. Involved in regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane. Acts upstream of or within signal transduction. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Orthologous to human TAMALIN (trafficking regulator and scaffold protein tamalin). [provided by Alliance of Genome Resources, Apr 2022]

Tamalin Products(1)

mRNA	Protein	Name
NM_019518.3	NP_062391.3	general receptor for phosphoinositides 1-associated scaffold protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10828067	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	32376687	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	32376687	MGI
acts upstream of or within signal transduction	IPI IPI: Inferred from physical interaction	10828067	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	32376687	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	32376687	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10828067	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

general receptor for phosphoinositides 1-associated scaffold protein

GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein

GRP1-associated scaffold protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14192	TAMALIN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tamalin	NCBI	NCBI:160622

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