Pals1 - protein associated with LIN7 1, MAGUK family member Gene

Mus musculus

Also known as Mpp5; 3830420B02Rik

Gene ID: 56217 | Gene type: protein coding

About Pals1

Summary

Predicted to enable guanylate kinase activity and protein domain specific binding activity. Involved in nervous system development; protein localization to myelin sheath abaxonal region; and regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within cellular protein localization; gene expression; and plasma membrane organization. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and myelin sheath adaxonal region. Is expressed in several structures, including cerebral cortex; early conceptus; eye; and future spinal cord neural plate. Used to study Leber congenital amaurosis. Orthologous to human PALS1 (protein associated with LIN7 1, MAGUK p55 family member). [provided by Alliance of Genome Resources, Apr 2022]

Pals1 Products(1)

mRNA	Protein	Name
NM_019579.3	NP_062525.1	protein PALS1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15316081	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in central nervous system neuron development	IMP IMP: Inferred from mutant phenotype	20399730	MGI
involved in cerebral cortex development	IMP IMP: Inferred from mutant phenotype	20399730	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	16885194	MGI
involved in peripheral nervous system myelin maintenance	IMP IMP: Inferred from mutant phenotype	20237282	MGI
acts upstream of or within plasma membrane organization	IMP IMP: Inferred from mutant phenotype	19506035	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	16885194	MGI
involved in protein localization to myelin sheath abaxonal region	IMP IMP: Inferred from mutant phenotype	20237282	MGI
involved in regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21145499	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	20237282	MGI
located in adherens junction	IDA IDA: Inferred from direct assay	21145499	MGI
is active in apical part of cell	IDA IDA: Inferred from direct assay	25636444	MGI
located in lateral loop	IDA IDA: Inferred from direct assay	20237282	MGI
located in myelin sheath adaxonal region	IDA IDA: Inferred from direct assay	20237282	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10753959	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein PALS1

MAGUK p55 subfamily member 5

membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 5)	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
protein associated with Lin-7 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-177596A	Dicytidine 5′-triphosphate trisodium	Activator	/	Unkown
HY-RS10009	PALS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-177596	Dicytidine 5′-triphosphate	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pals1	NCBI	NCBI:64398

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