Akap8 - A kinase (PRKA) anchor protein 8 Gene

Mus musculus

Also known as AKAP-8; AKAP95; 1200016A02Rik

Gene ID: 56399 | Gene type: protein coding

About Akap8

Summary

This gene encodes a member of the A-kinase anchoring protein (AKAP) family. These proteins are characterized by their ability to bind to the R subunit of protein kinase A (PKA) and anchor the protein at different subcellular locations. This protein has been shown to regulate Apoptosis and to be involved in palatogenesis. Knockdown of this gene has been associated with altered histone modifications and reduced expression of developmental genes in mouse embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Akap8 Products(2)

mRNA	Protein	Name
NM_001357760.1	NP_001344689.1	A-kinase anchor protein 8 isoform 2
NM_019774.5	NP_062748.2	A-kinase anchor protein 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IDA IDA: Inferred from direct assay	19531803	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16751186	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	19531803	MGI
involved in cellular response to prostaglandin E stimulus	IMP IMP: Inferred from mutant phenotype	19531803	MGI
acts upstream of or within mitotic chromosome condensation	IDA IDA: Inferred from direct assay	12082153	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	19531803	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in condensed chromosome	IDA IDA: Inferred from direct assay	12082153	MGI
located in female pronucleus	IDA IDA: Inferred from direct assay	12082153	MGI
located in nuclear matrix	IDA IDA: Inferred from direct assay	16751186	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12082153	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A-kinase anchor protein 8

A-kinase anchor protein 95 kDa

Akap8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Akap8	Q9DBR0	Fign	Mus musculus	Q9ERZ6	IF	16751186
Intra	Akap8	Q9DBR0	Fign	Mus musculus	Q9ERZ6	Anti Tag CoIP	16751186
Intra	Akap8	Q9DBR0	Fign	Mus musculus	Q9ERZ6	Y2H	16751186
Intra	Akap8	Q9DBR0	Nfkb1	Mus musculus	P25799	Anti Bait CoIP	19531803

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00523	AKAP8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00524	AKAP8L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akap8	NCBI	NCBI:10270

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