Akap8 - A kinase (PRKA) anchor protein 8 Gene

Also Known as AKAP-8; AKAP95; 1200016A02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56399

Summary

This gene encodes a member of the A-kinase anchoring protein (AKAP) family. These proteins are characterized by their ability to bind to the R subunit of protein kinase A (PKA) and anchor the protein at different subcellular locations. This protein has been shown to regulate Apoptosis and to be involved in palatogenesis. Knockdown of this gene has been associated with altered histone modifications and reduced expression of developmental genes in mouse embryonic stem cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Akap8 Products (2)

mRNA Protein Name
NM_001357760.1 NP_001344689.1 A-kinase anchor protein 8 isoform 2
NM_019774.5 NP_062748.2 A-kinase anchor protein 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NF-kappaB binding IDA
IDA: Inferred from direct assay
19531803 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16751186 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
19531803 MGI
involved in cellular response to prostaglandin E stimulus IMP
IMP: Inferred from mutant phenotype
19531803 MGI
acts upstream of or within mitotic chromosome condensation IDA
IDA: Inferred from direct assay
12082153 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
19531803 MGI
Cellular Component GO Annotation Evidence References Source
located in condensed chromosome IDA
IDA: Inferred from direct assay
12082153 MGI
located in female pronucleus IDA
IDA: Inferred from direct assay
12082153 MGI
located in nuclear matrix IDA
IDA: Inferred from direct assay
16751186 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12082153 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A-kinase anchor protein 8

  • A-kinase anchor protein 95 kDa

Akap8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Akap8 Q9DBR0 Fign Mus musculus Q9ERZ6
IF
16751186
Intra
Akap8 Q9DBR0 Fign Mus musculus Q9ERZ6
Anti Tag CoIP
16751186
Intra
Akap8 Q9DBR0 Fign Mus musculus Q9ERZ6
Y2H
16751186
Intra
Akap8 Q9DBR0 Nfkb1 Mus musculus P25799
Anti Bait CoIP
19531803
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00523 AKAP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00524 AKAP8L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akap8 NCBI NCBI:10270