Aldh18a1 - aldehyde dehydrogenase 18 family, member A1 Gene

Also Known as Pycs; 2810433K04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56454

Summary

Enables glutamate 5-kinase activity. Predicted to be involved in alpha-amino acid metabolic process and response to temperature stimulus. Predicted to act upstream of or within cellular amino acid biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; cardiovascular system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1). [provided by Alliance of Genome Resources, Apr 2022]

Aldh18a1 Products (2)

mRNA Protein Name
NM_019698.2 NP_062672.2 delta-1-pyrroline-5-carboxylate synthase isoform 1
NM_153554.2 NP_705782.2 delta-1-pyrroline-5-carboxylate synthase isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables glutamate 5-kinase activity IDA
IDA: Inferred from direct assay
10037775 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta-1-pyrroline-5-carboxylate synthase

  • P5CS

  • aldehyde dehydrogenase family 18 member A1

  • delta-1-pyrroline-5-carboxylate synthetase

  • glutamate gamma-semialdehyde synthetase

  • pyrroline-5-carboxylate synthetase (glutamate gamma-semialdehyde synthetase)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-156443 YG1702 Inhibitor 99.94% Unkown
HY-RS00559 ALDH18A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19101 Aldh18a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25590 Aldh18a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh18a1 NCBI NCBI:5832