Pkp3 - plakophilin 3 Gene

Also Known as 2310056L12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56460

Summary

Predicted to enable alpha-catenin binding activity; Cadherin binding activity; and enzyme binding activity. Predicted to be involved in several processes, including desmosome assembly; negative regulation of mRNA catabolic process; and protein localization to plasma membrane. Located in desmosome. Is expressed in skin. Orthologous to human PKP3 (plakophilin 3). [provided by Alliance of Genome Resources, Apr 2022]

Pkp3 Products (2)

mRNA Protein Name
NM_001162924.1 NP_001156396.1 plakophilin-3 isoform 2
NM_019762.2 NP_062736.2 plakophilin-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17535849 MGI
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
27375112 MGI
involved in desmosome assembly IMP
IMP: Inferred from mutant phenotype
27375112 MGI
involved in desmosome organization IMP
IMP: Inferred from mutant phenotype
18079750 MGI
involved in epithelial cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
18079750 MGI
involved in epithelial structure maintenance IMP
IMP: Inferred from mutant phenotype
26173741 MGI
involved in positive regulation of cell cycle G1/S phase transition IMP
IMP: Inferred from mutant phenotype
36689330 MGI
involved in positive regulation of cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
30949721 MGI
involved in positive regulation of protein localization IMP
IMP: Inferred from mutant phenotype
36689330 MGI
involved in regulation of cytokine production involved in immune response IMP
IMP: Inferred from mutant phenotype
26173741 MGI
involved in regulation of hair follicle development IMP
IMP: Inferred from mutant phenotype
18079750 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
27375112 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
26173741 MGI
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
27033150 MGI
located in desmosome IDA
IDA: Inferred from direct assay
14673151 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plakophilin-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10613 PKP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pkp3 NCBI NCBI:11187