Pkp3 - plakophilin 3 Gene

Mus musculus

Also known as 2310056L12Rik

Gene ID: 56460 | Gene type: protein coding

About Pkp3

Summary

Predicted to enable alpha-catenin binding activity; Cadherin binding activity; and enzyme binding activity. Predicted to be involved in several processes, including desmosome assembly; negative regulation of mRNA catabolic process; and protein localization to plasma membrane. Located in desmosome. Is expressed in skin. Orthologous to human PKP3 (plakophilin 3). [provided by Alliance of Genome Resources, Apr 2022]

Pkp3 Products(2)

mRNA	Protein	Name
NM_001162924.1	NP_001156396.1	plakophilin-3 isoform 2
NM_019762.2	NP_062736.2	plakophilin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17535849	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	27375112	MGI
involved in desmosome assembly	IMP IMP: Inferred from mutant phenotype	27375112	MGI
involved in desmosome organization	IMP IMP: Inferred from mutant phenotype	18079750	MGI
involved in epithelial cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	18079750	MGI
involved in epithelial structure maintenance	IMP IMP: Inferred from mutant phenotype	26173741	MGI
involved in positive regulation of cell cycle G1/S phase transition	IMP IMP: Inferred from mutant phenotype	36689330	MGI
involved in positive regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	30949721	MGI
involved in positive regulation of protein localization	IMP IMP: Inferred from mutant phenotype	36689330	MGI
involved in regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	26173741	MGI
involved in regulation of hair follicle development	IMP IMP: Inferred from mutant phenotype	18079750	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	27375112	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	26173741	MGI
is active in cornified envelope	IDA IDA: Inferred from direct assay	26644517	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	27033150	MGI
located in desmosome	IDA IDA: Inferred from direct assay	14673151	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

plakophilin-3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10613	PKP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pkp3	NCBI	NCBI:11187

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