Socs5 - suppressor of cytokine signaling 5 Gene

Also Known as Cish5; mKIAA0671; 1810018L08Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56468

Summary

Enables epidermal growth factor receptor binding activity. Involved in several processes, including cellular response to low-density lipoprotein particle stimulus; negative regulation of cytokine production; and regulation of T-helper cell differentiation. Acts upstream of or within epidermal growth factor receptor signaling pathway. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in retina. Orthologous to human SOCS5 (suppressor of cytokine signaling 5). [provided by Alliance of Genome Resources, Apr 2022]

Socs5 Products (1)

mRNA	Protein	Name
NM_019654.2	NP_062628.2	suppressor of cytokine signaling 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables epidermal growth factor receptor binding	IPI IPI: Inferred from physical interaction	15695332	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12242343	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to low-density lipoprotein particle stimulus	IMP IMP: Inferred from mutant phenotype	24255059	MGI
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	12242343	MGI
acts upstream of or within epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15695332	MGI
involved in negative regulation of T-helper 2 cell differentiation	IDA IDA: Inferred from direct assay	12242343	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	24255059	MGI
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	24255059	MGI
involved in negative regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	24255059	MGI
involved in positive regulation of T-helper 1 cell differentiation	IDA IDA: Inferred from direct assay	12242343	MGI
involved in vascular endothelial cell response to fluid shear stress	IMP IMP: Inferred from mutant phenotype	24255059	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
suppressor of cytokine signaling 5	SOCS-5 cytokine inducible SH2-containing protein 5

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13556	SOCS5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Socs5	NCBI	NCBI:9655