SOCS5 - suppressor of cytokine signaling 5 Gene

Also Known as CIS6; CISH6; Cish5; SOCS-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9655

About SOCS5

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:46,698,937-46,763,129 (from NCBI)

This gene has 4 transcripts (splice variants), 196 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 13.6), endometrium (RPKM 9.7) and 25 other tissues.

Summary

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT Inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

SOCS5 Products (2)

mRNA	Protein	Name
NM_014011.5	NP_054730.1	suppressor of cytokine signaling 5
NM_144949.3	NP_659198.1	suppressor of cytokine signaling 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15590694	GOA
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	15590694	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of epidermal growth factor-activated receptor activity	IDA IDA: Inferred from direct assay	15590694	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	15590694	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOCS5 Protein Structure

SOCS

SH2

SOCS_box

0
100
200
300
400
500
536 a.a.

Protein Preferred Names	Protein Names
suppressor of cytokine signaling 5	CIS-6

SOCS5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SOCS5	O75159	MET	Homo sapiens	P08581	FPS	24728074

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Conjunctivitis	Madras Eye Adenoviral Conjunctivitis Acute Adenoviral Follicular Conjunctivitis Inclusion Conjunctivitis Of The Adult Swimming-Pool Conjunctivitis Inflammation Of Conjunctiva Ophthalmia Acute Conjunctivitis Eye Catarrh Catarrhal Ophthalmia Koch-Weeks Conjunctivitis
Small Intestine Leiomyosarcoma	Leiomyosarcoma Of The Small Bowel Smooth Muscle Connective Tissue Tumor Leiomyosarcoma Of Small Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13556	SOCS5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SOCS5	MGD	MGI:2385459
Canis familiaris	SOCS5	VGNC	VGNC:46652
Macaca mulatta	SOCS5	VGNC	VGNC:106222
Felis catus	SOCS5	VGNC	VGNC:65564
Bos taurus	SOCS5	VGNC	VGNC:35123
Rattus norvegicus	SOCS5	RGD	RGD:1564914
Others	SOCS5	NCBI