2. Gene
  3. SOCS5 - suppressor of cytokine signaling 5 Gene

SOCS5 - suppressor of cytokine signaling 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CIS6; CISH6; Cish5; SOCS-5

Gene ID: 9655 | Gene type: protein coding

About SOCS5

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:46,698,937-46,763,129 (from NCBI)

This gene has 4 transcripts (splice variants), 196 orthologues and 7 paralogues. Ubiquitous expression in ovary (RPKM 13.6), endometrium (RPKM 9.7) and 25 other tissues.

Summary

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT Inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]

SOCS5 Products(2)

mRNA Protein Name
NM_014011.5 NP_054730.1 suppressor of cytokine signaling 5
NM_144949.3 NP_659198.1 suppressor of cytokine signaling 5

SOCS5 Protein Structure

SOCS

SOCS: Suppressor of cytokine signalling (144 - 197)

SH2

SH2: SH2 domain (382 - 436)

SOCS_box

SOCS_box: SOCS box (481 - 518)

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  • 536 a.a.
Protein Preferred Names Protein Names

suppressor of cytokine signaling 5

CIS-6

Related Diseases

Diseases Alias
Conjunctivitis

Madras Eye

Adenoviral Conjunctivitis

Acute Adenoviral Follicular Conjunctivitis

Inclusion Conjunctivitis Of The Adult

Swimming-Pool Conjunctivitis

Inflammation Of Conjunctiva

Ophthalmia

Acute Conjunctivitis

Eye Catarrh

Catarrhal Ophthalmia

Koch-Weeks Conjunctivitis
Small Intestine Leiomyosarcoma

Leiomyosarcoma Of The Small Bowel

Smooth Muscle Connective Tissue Tumor

Leiomyosarcoma Of Small Intestine
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13556 SOCS5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SOCS5 MGD MGI:2385459
Canis familiaris SOCS5 VGNC VGNC:46652
Macaca mulatta SOCS5 VGNC VGNC:106222
Felis catus SOCS5 VGNC VGNC:65564
Bos taurus SOCS5 VGNC VGNC:35123
Rattus norvegicus SOCS5 RGD RGD:1564914