Pias1 - protein inhibitor of activated STAT 1 Gene

Also Known as GBP; Ddxbp1; 2900068C24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56469

Summary

Enables SUMO transferase activity and ubiquitin protein Ligase binding activity. Involved in several processes, including fat cell differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and protein sumoylation. Located in nucleus. Colocalizes with PML body. Is expressed in several structures, including branchial arch; genitourinary system; sensory organ; tooth; and trunk mesenchyme. Orthologous to human PIAS1 (protein inhibitor of activated STAT 1). [provided by Alliance of Genome Resources, Apr 2022]

Pias1 Products (1)

mRNA Protein Name
NM_019663.3 NP_062637.2 E3 SUMO-protein ligase PIAS1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
24061474 MGI
enables SUMO ligase activity IDA
IDA: Inferred from direct assay
16600910 MGI
enables SUMO transferase activity EXP
EXP: Inferred from Experiment
15123625 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14611647 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
16600910 MGI
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
16816390 MGI
Biological Process GO Annotation Evidence References Source
involved in fat cell differentiation IDA
IDA: Inferred from direct assay
24061474 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16127449 MGI
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
22406621 MGI
involved in positive regulation of protein localization to cell periphery IDA
IDA: Inferred from direct assay
16600910 MGI
involved in protein sumoylation IDA
IDA: Inferred from direct assay
22406621 MGI
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
22406621 MGI
Cellular Component GO Annotation Evidence References Source
colocalizes with PML body IDA
IDA: Inferred from direct assay
22406621 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34459572 MGI
located in nuclear periphery IDA
IDA: Inferred from direct assay
16600910 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16522640 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
34459572 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
34459572 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 SUMO-protein ligase PIAS1

  • DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1

  • DEAD/H box-binding protein 1

  • RING-type E3 ubiquitin transferase PIAS1

  • protein inhibitor of activated STAT protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W062696 BC-1382 Inhibitor 99.36% Unkown
HY-RS10473 PIAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20081 Pias1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26584 Pias1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pias1 NCBI NCBI:8554