Ruvbl1 - RuvB-like protein 1 Gene

Also Known as Tip49a; Pontin52; 2510009G06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56505

Summary

Enables ATPase binding activity; TFIID-class transcription factor complex binding activity; and adenyl ribonucleotide binding activity. Predicted to be involved in several processes, including box C/D snoRNP assembly; histone acetylation; and regulation of gene expression. Predicted to act upstream of or within several processes, including DNA metabolic process; chromatin organization; and regulation of growth. Part of ribonucleoprotein complex. Is expressed in several structures, including branchial arch; limb; liver; maxillary process; and sensory organ. Orthologous to human RUVBL1 (RuvB like AAA ATPase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ruvbl1 Products (1)

mRNA Protein Name
NM_019685.3 NP_062659.1 ruvB-like 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP binding IDA
IDA: Inferred from direct assay
17636026 MGI
enables ATP binding IDA
IDA: Inferred from direct assay
17636026 MGI
enables ATPase binding IPI
IPI: Inferred from physical interaction
17636026 MGI
enables TFIID-class transcription factor complex binding IPI
IPI: Inferred from physical interaction
17636026 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17636026 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA repair IDA
IDA: Inferred from direct assay
23979016 MGI
involved in positive regulation of telomere maintenance in response to DNA damage IMP
IMP: Inferred from mutant phenotype
23979016 MGI
involved in regulation of DNA repair IDA
IDA: Inferred from direct assay
23979016 MGI
involved in regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
23979016 MGI
involved in telomere maintenance IMP
IMP: Inferred from mutant phenotype
23979016 MGI
Cellular Component GO Annotation Evidence References Source
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
19299493 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ruvB-like 1

  • 49 kDa TATA box-binding protein-interacting protein

  • 49 kDa TBP-interacting protein

  • DNA helicase p50

  • Pontin 52

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114429 CB-6644 Inhibitor 99.85% Unkown
HY-146074 RUVBL1/2 ATPase-IN-1 Inhibitor 99.63% Unkown
HY-103702 TIP48/49-IN-1 99.07% Unkown
HY-183643 RUVBL1/2-IN-1 / Unkown
HY-RS12354 RUVBL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17564 Ruvbl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24024 Ruvbl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ruvbl1 NCBI NCBI:8607