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CB-6644 

Cat. No.: HY-114429
Handling Instructions

CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM.

For research use only. We do not sell to patients.

CB-6644 Chemical Structure

CB-6644 Chemical Structure

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CB-6644 is a selective inhibitor of RUVBL1/2 complex with anti-cancer activity. CB-6644 blocks the ATPase activity of RUVBL1/2 with an IC50 of 15 nM[1].

In Vitro

CB-6644 (20 µM) interacts with the RUVBL1/2 complex in Ramos cells[1].
CB-6644 (0.4 µM, 80 hours) dramatically inhibits HCT116 cells growth rate and robustly induces apoptosis. Z-VAD-FMK alone does not influence the growth or viability of the cells. However, blockade of caspase activity by Z-VAD-FMK results in a partial recovery of the growth of cells treated with CB-6644[1].

Cell Viability Assay[1]

Cell Line: HCT116 cells
Concentration: 0.4 µM
Incubation Time: 80 hours
Result: Inhibited dramatically cell growth rate.
In Vivo

CB-6644 (150 mg/kg, oral administration, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models, 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models) has antitumor activity in xenograft tumor models with tumor growth inhibitions (TGIs) of 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models[1].

Animal Model: SCID-beige mice bearing human tumor xenografts derived from either Burkitt’s lymphoma (Ramos) or multiple myeloma (RPMI8226) cell lines[1]
Dosage: 150 mg/kg
Administration: Oral gavage once (qd) or twice (BID) daily, 10 days of treatment for Ramos, 30 days of treatment for RPMI8226
Result: There was no significant bodyweight loss in mice. TGI of 68 and 81% in Ramos and RPMI8226, respectively.
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7450 mL 8.7251 mL 17.4502 mL
5 mM 0.3490 mL 1.7450 mL 3.4900 mL
10 mM 0.1745 mL 0.8725 mL 1.7450 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

573.06

Formula

C₂₉H₃₄ClFN₄O₅

SMILES

COCC1=C(NC(CC(C)(C)CNC(C2=C(OCC)C=C(F)C(Cl)=C2)=O)=O)C(N(N1CCC3)C4=C3C=CC=C4)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
CB-6644
Cat. No.:
HY-114429
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CB-6644

Cat. No.: HY-114429