Clec4n - C-type lectin domain family 4, member n Gene

Also Known as Nkcl; Clec6a; Clecsf10

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56620

Summary

Enables carbohydrate binding activity and pattern recognition receptor activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of immune response; and response to fungus. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in bone marrow; embryo; lung; spleen; and thymus. Orthologous to human CLEC6A (C-type lectin domain containing 6A). [provided by Alliance of Genome Resources, Apr 2022]

Clec4n Products (3)

mRNA Protein Name
NM_001190320.1 NP_001177249.1 C-type lectin domain family 6 member A isoform 2
NM_001190321.1 NP_001177250.1 C-type lectin domain family 6 member A isoform 3
NM_020001.2 NP_064385.1 C-type lectin domain family 6 member A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables carbohydrate binding IDA
IDA: Inferred from direct assay
20493731 MGI
enables pattern recognition receptor activity IMP
IMP: Inferred from mutant phenotype
22041900 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17050534 MGI
Biological Process GO Annotation Evidence References Source
involved in antifungal innate immune response IMP
IMP: Inferred from mutant phenotype
22041900 MGI
involved in defense response to fungus IDA
IDA: Inferred from direct assay
20493731 MGI
involved in detection of yeast IMP
IMP: Inferred from mutant phenotype
22041900 MGI
involved in innate immune response IDA
IDA: Inferred from direct assay
17050534 MGI
involved in positive regulation of T-helper 17 type immune response IMP
IMP: Inferred from mutant phenotype
32358020 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
17050534 MGI
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
20493731 MGI
involved in positive regulation of intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
22041900 MGI
acts upstream of positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
22041900 MGI
involved in response to yeast IMP
IMP: Inferred from mutant phenotype
22041900 MGI
involved in stimulatory C-type lectin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
22041900 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-type lectin domain family 6 member A

  • C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 10

  • C-type lectin superfamily member 10

  • DC-associated C-type lectin 2

  • dectin-2

  • dendritic cell-associated C-type lectin 2

  • natural killer complex lectin

Recombinant Clec4n Proteins

Cat. No. Product Name Accession Purity
HY-P72967 Dectin-2/CLEC6A Protein, Mouse (HEK293, His) Q9JKF4-1/NP_064385.1 (I44-L209) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02799 CLEC6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown