PSG3 - pregnancy specific beta-1-glycoprotein 3 Gene

Homo sapiens

Gene ID: 5671 | Gene type: protein coding

About PSG3

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,721,642-42,740,481 (from NCBI)

This gene has 6 transcripts (splice variants), 627 orthologues and 24 paralogues. Restricted expression toward placenta (RPKM 164.7).

Summary

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

PSG3 Products(1)

mRNA	Protein	Name
NM_021016.4	NP_066296.2	pregnancy-specific beta-1-glycoprotein 3 precursor

PSG3 Protein Structure

V-set

Ig_2

0
100
200
300
400
428 a.a.

Protein Preferred Names

Protein Names

pregnancy-specific beta-1-glycoprotein 3

PS-beta-G-3

Recombinant PSG3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71239	PSG3 Protein, Human (HEK293, His)	Q16557 (Q35-L428)	≥95%

Related Diseases

Diseases

Alias

Twin-To-Twin Transfusion Syndrome

Twin To Twin Transfusion Syndrome	Twin Twin Transfusion Syndrome
Fetal Blood Loss From Fetal Hemorrhage Into Co-Twin	Fetal Hemorrhage Into Co-Twin
Twin To Twin Transfusion	Twin-To-Twin Blood Transfer
Fetal Transfusion Syndrome	Fetofetal Transfusion Syndrome
Ttts	Feto-Fetal Transfusion Syndrome
Fetofetal Transfusion	Fetus-To-Fetus Placental Transfusion Syndrome

Spondyloepiphyseal Dysplasia, Nishimura Type

SEDN	Spondyloepiphyseal Dysplasia Nishimura Type