Ascl3 - achaete-scute family bHLH transcription factor 3 Gene

Mus musculus

Also known as Sgn1; bHLHa42

Gene ID: 56787 | Gene type: protein coding

About Ascl3

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in parotid gland; sublingual gland; submandibular gland; and ureter. Orthologous to human ASCL3 (achaete-scute family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ascl3 Products(1)

mRNA	Protein	Name
NM_020051.1	NP_064435.1	achaete-scute homolog 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11784080	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11784080	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11784080	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11784080	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in epithelium development	IMP IMP: Inferred from mutant phenotype	27910949	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11784080	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11784080	MGI
involved in salivary gland development	IMP IMP: Inferred from mutant phenotype	18572159	MGI
involved in sensory epithelium regeneration	IMP IMP: Inferred from mutant phenotype	27910949	MGI
involved in tissue homeostasis	IMP IMP: Inferred from mutant phenotype	21377457	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	11784080	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	11784080	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

achaete-scute homolog 3

ASH-3	ICRFP703B1614Q5.4
ICRFP703N2430Q5.4	achaete-scute complex homolog 3
achaete-scute complex homolog-like 3	bHLH transcriptional regulator Sgn-1
mASH-3	mASH3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01080	ASCL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ascl3	NCBI	NCBI:56676

Name
Email *

	Sorry, but the email address you supplied was invalid.