Ascl3 - achaete-scute family bHLH transcription factor 3 Gene

Also Known as Sgn1; bHLHa42

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56787

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in parotid gland; sublingual gland; submandibular gland; and ureter. Orthologous to human ASCL3 (achaete-scute family bHLH transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Ascl3 Products (1)

mRNA Protein Name
NM_020051.1 NP_064435.1 achaete-scute homolog 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11784080 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11784080 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11784080 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11784080 MGI
Biological Process GO Annotation Evidence References Source
involved in epithelium development IMP
IMP: Inferred from mutant phenotype
27910949 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11784080 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11784080 MGI
involved in salivary gland development IMP
IMP: Inferred from mutant phenotype
18572159 MGI
involved in sensory epithelium regeneration IMP
IMP: Inferred from mutant phenotype
27910949 MGI
involved in tissue homeostasis IMP
IMP: Inferred from mutant phenotype
21377457 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11784080 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
11784080 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

achaete-scute homolog 3

  • ASH-3

  • ICRFP703B1614Q5.4

  • ICRFP703N2430Q5.4

  • achaete-scute complex homolog 3

  • achaete-scute complex homolog-like 3

  • bHLH transcriptional regulator Sgn-1

  • mASH-3

  • mASH3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01080 ASCL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ascl3 NCBI NCBI:56676