ENY2 - ENY2 transcription and export complex 2 subunit Gene

Also Known as DC6; Sus1; e(y)2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56943

About ENY2

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:109,334,347-109,345,954 (from NCBI)

This gene has 16 transcripts (splice variants) and 261 orthologues. Ubiquitous expression in kidney (RPKM 15.2), bone marrow (RPKM 14.0) and 25 other tissues.

Summary

Enables nuclear receptor coactivator activity. Involved in histone deubiquitination; poly(A)+ mRNA export from nucleus; and positive regulation of transcription, DNA-templated. Located in mitochondrion and nucleoplasm. Part of nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ENY2 Products (2)

mRNA Protein Name
NM_001193557.2 NP_001180486.1 transcription and mRNA export factor ENY2 isoform 2
NM_020189.6 NP_064574.1 transcription and mRNA export factor ENY2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
18206972 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23591820 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
18206972 GOA
Biological Process GO Annotation Evidence References Source
involved in poly(A)+ mRNA export from nucleus IMP
IMP: Inferred from mutant phenotype
23591820 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18206972 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9603525 GOA
Cellular Component GO Annotation Evidence References Source
part of DUBm complex IDA
IDA: Inferred from direct assay
27601583 GOA
part of SAGA complex IDA
IDA: Inferred from direct assay
18206972 GOA
part of nuclear pore nuclear basket IDA
IDA: Inferred from direct assay
23591820 GOA
part of transcription export complex 2 IDA
IDA: Inferred from direct assay
23591820 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENY2 Protein Structure

EnY2

EnY2: Transcription factor e(y)2 (11 - 95)

  • 0
  • 101 a.a.
Protein Preferred Names Protein Names

transcription and mRNA export factor ENY2

  • enhancer of yellow 2 homolog

ENY2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ENY2 Q9NPA8 ATXN7L3 Homo sapiens Q14CW9
Y2H Array
32296183
Intra
ENY2 Q9NPA8 ATXN7L3 Homo sapiens Q14CW9
Anti Tag CoIP
35271311
Intra
ENY2 Q9NPA8 ATXN7L3 Homo sapiens Q14CW9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 7

  • Spinocerebellar Ataxia Type 7

  • SCA7

  • Opca3

  • Opca Iii

  • Olivopontocerebellar Atrophy Iii

  • Opca With Retinal Degeneration

  • Opca With Macular Degeneration And External Ophthalmoplegia

  • Adca, Type Ii

  • Autosomal Dominant Cerebellar Ataxia Type 2

  • Olivopontocerebellar Atrophy 3

  • Autosomal Dominant Cerebellar Ataxia, Type Ii

  • Autosomal Dominant Cerebellar Ataxia Type Ii

  • Adca2

  • Adcaii

  • Ataxia With Pigmentary Retinopathy

  • Cerebellar Syndrome-Pigmentary Maculopathy Syndrome

  • Olivopontocerebellar Atrophy With Retinal Degeneration

  • Spinocerebellar Ataxia-7

  • Ataxia, Spinocerebellar, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04402 ENY2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W657887 GSK-3β/G9a-IN-1 Inhibitor / Unkown
HY-RS22160 Eny2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28682 Eny2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ENY2 RGD RGD:1596439
Macaca mulatta ENY2 VGNC VGNC:104451
Felis catus ENY2 VGNC VGNC:61886
Mus musculus ENY2 MGD MGI:1919286
Bos taurus ENY2 VGNC VGNC:28514
Others ENY2 NCBI