2. Gene
  3. ADAM22 - Adam22 ADAM metallopeptidase domain 22 Gene

ADAM22 - Adam22 ADAM metallopeptidase domain 22 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as MDC2

Gene ID: 57033 | Gene type: protein coding

About ADAM22

Summary

Predicted to enable metalloendopeptidase activity. Predicted to be involved in neurotransmitter receptor localization to postsynaptic specialization membrane. Predicted to act upstream of or within adult locomotory behavior and myelination in peripheral nervous system. Predicted to be located in axon and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in glutamatergic synapse. Predicted to be integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Orthologous to human ADAM22 (ADAM metallopeptidase domain 22). [provided by Alliance of Genome Resources, Apr 2022]

ADAM22 Products(14)

mRNA Protein Name
XM_039108562.1 XP_038964490.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X2
XM_039108561.1 XP_038964489.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X1
XM_039108564.1 XP_038964492.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X4
XM_039108563.1 XP_038964491.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X3
XM_039108565.1 XP_038964493.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X5
XM_039108566.1 XP_038964494.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X6
XM_039108567.1 XP_038964495.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X7
XM_039108569.1 XP_038964497.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X9
XM_039108568.1 XP_038964496.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X8
XM_039108571.1 XP_038964499.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X11
XM_039108573.1 XP_038964501.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X13
XM_039108574.1 XP_038964502.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X14
XM_039108570.1 XP_038964498.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X10
XM_039108572.1 XP_038964500.1 disintegrin and metalloproteinase domain-containing protein 22 isoform X12
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of protein localization IMP
IMP: Inferred from mutant phenotype
30598502 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon initial segment IDA
IDA: Inferred from direct assay
30598502 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 22

a disintegrin and metalloprotease domain (ADAM) 22

a disintegrin and metalloprotease domain 22

disintegrin and metalloproteinase domain-containing protein 22-like

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00278 ADAM22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ADAM22 NCBI NCBI:53616