Slc12a5 - solute carrier family 12, member 5 Gene

Also Known as KCC2; mKIAA1176

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57138

Summary

Enables potassium:chloride symporter activity. Acts upstream of or within several processes, including chloride transport; learning; and thermosensory behavior. Located in dendritic shaft; neuronal cell body; and plasma membrane. Is expressed in several structures, including central nervous system and retina. Used to study epilepsy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 34 and idiopathic generalized epilepsy 14. Orthologous to human SLC12A5 (solute carrier family 12 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc12a5 Products (3)

mRNA Protein Name
NM_001355480.1 NP_001342409.1 solute carrier family 12 member 5 isoform 1
NM_001355481.1 NP_001342410.1 solute carrier family 12 member 5 isoform 2
NM_020333.2 NP_065066.2 solute carrier family 12 member 5 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables potassium:chloride symporter activity IMP
IMP: Inferred from mutant phenotype
11395011 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
11395011 MGI
acts upstream of or within chloride transport IMP
IMP: Inferred from mutant phenotype
11395011 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
15813942 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
15813942 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
15813942 MGI
acts upstream of or within thermosensory behavior IMP
IMP: Inferred from mutant phenotype
15813942 MGI
Cellular Component GO Annotation Evidence References Source
located in cell periphery IDA
IDA: Inferred from direct assay
25716834 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
25716834 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11395011 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
11395011 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 12 member 5

  • K-Cl cotransporter 2

  • electroneutral potassium-chloride cotransporter 2

  • mKCC2

  • neuronal K-Cl cotransporter

Slc12a5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87092 Slc12a5/KCC2 Antibody (YA6785) IHC-F, WB Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-160082 KCC2 Modulator-2 Modulator / Unkown
HY-RS13000 SLC12A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc12a5 NCBI NCBI:57468