Xrcc2 - X-ray repair complementing defective repair in Chinese hamster cells 2 Gene

Also Known as RecA; RAD51; 4921524O04Rik; 8030409M04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57434

Summary

Predicted to enable ATP binding activity; ATP-dependent activity, acting on DNA; and DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Acts upstream of or within several processes, including chordate embryonic development; regulation of apoptotic process; and response to X-ray. Predicted to be located in nucleoplasm. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in centrosome and replication fork. Is expressed in embryo. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group U; pancreatic cancer; primary ovarian insufficiency 17; and spermatogenic failure 50. Orthologous to human XRCC2 (X-ray repair cross complementing 2). [provided by Alliance of Genome Resources, Apr 2022]

Xrcc2 Products (1)

mRNA Protein Name
NM_020570.2 NP_065595.2 DNA repair protein XRCC2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19327148 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
15979950 MGI
acts upstream of or within double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
16777961 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
16777961 MGI
acts upstream of or within multicellular organism growth IGI
IGI: Inferred from genetic interaction
17116431 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
16777961 MGI
acts upstream of neurogenesis IMP
IMP: Inferred from mutant phenotype
16777961 MGI
acts upstream of or within neurogenesis IMP
IMP: Inferred from mutant phenotype
17116431 MGI
acts upstream of or within positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
16777961 MGI
acts upstream of or within regulation of fibroblast apoptotic process IGI
IGI: Inferred from genetic interaction
17116431 MGI
acts upstream of or within response to X-ray IMP
IMP: Inferred from mutant phenotype
15979950 MGI
acts upstream of or within response to gamma radiation IMP
IMP: Inferred from mutant phenotype
16777961 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
17116431 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA repair protein XRCC2

  • X-ray repair cross-complementing protein 2

  • recA/RAD51 family protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15897 XRCC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xrcc2 NCBI NCBI:7516