Xrcc2 - X-ray repair complementing defective repair in Chinese hamster cells 2 Gene

Mus musculus

Also known as RecA; RAD51; 4921524O04Rik; 8030409M04Rik

Gene ID: 57434 | Gene type: protein coding

About Xrcc2

Summary

Predicted to enable ATP binding activity; ATP-dependent activity, acting on DNA; and DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Acts upstream of or within several processes, including chordate embryonic development; regulation of apoptotic process; and response to X-ray. Predicted to be located in nucleoplasm. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in centrosome and replication fork. Is expressed in embryo. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group U; pancreatic cancer; primary ovarian insufficiency 17; and spermatogenic failure 50. Orthologous to human XRCC2 (X-ray repair cross complementing 2). [provided by Alliance of Genome Resources, Apr 2022]

Xrcc2 Products(1)

mRNA	Protein	Name
NM_020570.2	NP_065595.2	DNA repair protein XRCC2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19327148	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	15979950	MGI
acts upstream of or within double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	16777961	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	16777961	MGI
acts upstream of or within multicellular organism growth	IGI IGI: Inferred from genetic interaction	17116431	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	16777961	MGI
acts upstream of neurogenesis	IMP IMP: Inferred from mutant phenotype	16777961	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	17116431	MGI
acts upstream of or within positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	16777961	MGI
acts upstream of or within regulation of fibroblast apoptotic process	IGI IGI: Inferred from genetic interaction	17116431	MGI
acts upstream of or within response to X-ray	IMP IMP: Inferred from mutant phenotype	15979950	MGI
acts upstream of or within response to gamma radiation	IMP IMP: Inferred from mutant phenotype	16777961	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	17116431	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DNA repair protein XRCC2

X-ray repair cross-complementing protein 2

recA/RAD51 family protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15897	XRCC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xrcc2	NCBI	NCBI:7516

Name
Email *

	Sorry, but the email address you supplied was invalid.