Gmnn - geminin Gene

Also Known as Gem

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57441

Summary

Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in negative regulation of cell cycle; negative regulation of cellular macromolecule biosynthetic process; and protein-containing complex assembly. Acts upstream of or within animal organ morphogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 6. Orthologous to human GMNN (geminin DNA replication inhibitor). [provided by Alliance of Genome Resources, Apr 2022]

Gmnn Products (1)

mRNA Protein Name
NM_020567.2 NP_065592.1 geminin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16924111 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12192004 MGI
NOT enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
16924111 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
16924111 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within animal organ morphogenesis IDA
IDA: Inferred from direct assay
9671596 MGI
involved in negative regulation of DNA replication IDA
IDA: Inferred from direct assay
12192004 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16924111 MGI
involved in negative regulation of cell cycle IDA
IDA: Inferred from direct assay
12192004 MGI
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
16924111 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9671596 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

geminin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05523 GMNN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180858 GMNN modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gmnn NCBI NCBI:51053