TENM2 - teneurin transmembrane protein 2 Gene

Also Known as ODZ2; TEN2; TNM2; ten-2; TEN-M2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57451

About TENM2

Cytogenetic location: 5q34 Genomic coordinates (GRCh38): 5:166,979,029-168,264,157 (from NCBI)

This gene has 15 transcripts (splice variants), 255 orthologues and 4 paralogues. Biased expression in heart (RPKM 7.7), brain (RPKM 2.7) and 6 other tissues.

Summary

Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including calcium-mediated signaling using intracellular calcium source; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and retrograde trans-synaptic signaling by trans-synaptic protein complex. Located in cell-cell junction and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TENM2 Products (5)

mRNA	Protein	Name
NM_001080428.3	NP_001073897.2	teneurin-2 isoform 2
NM_001122679.2	NP_001116151.1	teneurin-2 isoform 1
NM_001368145.1	NP_001355074.1	teneurin-2 isoform 3
NM_001368146.1	NP_001355075.1	teneurin-2 isoform 4
NM_001395460.1	NP_001382389.1	teneurin-2 isoform 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cell adhesion molecule binding	IDA IDA: Inferred from direct assay	21724987	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21724987	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	21724987	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in retrograde trans-synaptic signaling by trans-synaptic protein complex	EXP EXP: Inferred from Experiment	21724987	GOA
involved in retrograde trans-synaptic signaling by trans-synaptic protein complex	IDA IDA: Inferred from direct assay	21724987	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	21724987	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21724987	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TENM2 Protein Structure

Ten_N

Tox-GHH

0
500
1000
1500
2000
2500
2774 a.a.

Protein Preferred Names	Protein Names
teneurin-2	neurestin alpha

Recombinant TENM2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P701072	TENM2 Protein, Human (HEK293, His)	Q9NT68-1 (G401-N841)	≥ 90%, as determined by reducing Bis-Tris PAGE.

Related Diseases

Diseases	Alias
Rapp-Hodgkin Syndrome	RHS Anhidrotic Ectodermal Dysplasia With Cleft Lip/Palate Ectodermal Dysplasia, Rapp-Hodgkin Type Rapp-Hodgkin Ectodermal Dysplasia Syndrome Ectodermal Dysplasia, Anhidrotic, With Cleft Lip/Palate Ectodermal Dysplasia Syndrome, Rapp-Hodgkin Type Edrh Rapp-Hodgkin Ectodermal Dysplasia Orofacial Cleft 8
Ornithosis	Psittacosis Chlamydial Pneumonia Chlamydia Psittaci Infection Chlamydia Psittaci
Usher Syndrome, Type Iic	Usher Syndrome Type 2c USH2C Usher Syndrome, Type 2c Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic Usher Syndrome Type Iic Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic Usher Syndrome 2c Usher'S Syndrome Type 2c Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14363	TENM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TENM2	VGNC	VGNC:66070
Rattus norvegicus	TENM2	RGD	RGD:727907
Macaca mulatta	TENM2	VGNC	VGNC:79829
Mus musculus	TENM2	MGD	MGI:1345184
Canis familiaris	TENM2	VGNC	VGNC:47247
Bos taurus	TENM2	VGNC	VGNC:35742
Others	TENM2	NCBI