TENM2 Protein, Human (HEK293, His)

TENM2 Protein plays a crucial role in neural development, facilitating proper connectivity in the nervous system by promoting filopodia formation and enlarged growth cones in neurons. It functions as a ligand for the ADGRL1 receptor, mediating axon guidance and heterophilic cell-cell adhesion. TENM2 Protein, Human (HEK293, His) is the recombinant human-derived TENM2 protein, expressed by HEK293 , with N-His labeled tag.

TENM2 protein plays a crucial role in neural development by regulating the establishment of precise connectivity within the nervous system. It facilitates the formation of filopodia and enlarged growth cones in neuronal cells, highlighting its involvement in the intricate processes of neurite outgrowth. Additionally, TENM2 acts as a mediator of homophilic cell-cell adhesion, contributing to cell interactions during neural development. Functioning as a ligand for the ADGRL1 receptor, it further participates in axon guidance and heterophilic cell-cell adhesion, emphasizing its multifaceted role as a cellular signal transducer.

Human

HEK293

N-8*His

Q9NT68-1 (G401-N841)

/

Partial

GLNWQLQPADGHTFNNGIRTGLPGNDDVATMPSGGKVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCN

Approximately 55-65 kDa & 38-43 kDa & 25-30 kDa, based on Bis-Tris PAGE under reducing conditions.

≥ 90%, as determined by reducing Bis-Tris PAGE.

Lyophilized powder

Lyophilized from a 0.22 μm filtered solution of PBS, 2mM DTT, pH 7.4, 8% trehalose.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.