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TENM2 Protein, Human (HEK293, His)

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TENM2 Protein plays a crucial role in neural development, facilitating proper connectivity in the nervous system by promoting filopodia formation and enlarged growth cones in neurons. It functions as a ligand for the ADGRL1 receptor, mediating axon guidance and heterophilic cell-cell adhesion. TENM2 Protein, Human (HEK293, His) is the recombinant human-derived TENM2 protein, expressed by HEK293 , with N-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

TENM2 Protein plays a crucial role in neural development, facilitating proper connectivity in the nervous system by promoting filopodia formation and enlarged growth cones in neurons. It functions as a ligand for the ADGRL1 receptor, mediating axon guidance and heterophilic cell-cell adhesion. TENM2 Protein, Human (HEK293, His) is the recombinant human-derived TENM2 protein, expressed by HEK293 , with N-His labeled tag.

Background

TENM2 protein plays a crucial role in neural development by regulating the establishment of precise connectivity within the nervous system. It facilitates the formation of filopodia and enlarged growth cones in neuronal cells, highlighting its involvement in the intricate processes of neurite outgrowth. Additionally, TENM2 acts as a mediator of homophilic cell-cell adhesion, contributing to cell interactions during neural development. Functioning as a ligand for the ADGRL1 receptor, it further participates in axon guidance and heterophilic cell-cell adhesion, emphasizing its multifaceted role as a cellular signal transducer.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag N-8*His
  • Accession

    Q9NT68-1 (G401-N841)

  • Gene ID
    /
  • Molecular Construction
    • N-term
    • 8*His
    • TENM2 (G401-N841)
      Accession # Q9NT68-1
    • C-term
  • Protein Length

    Partial Extracellular Domain

  • Synonyms

    TENM2; TEN2; Prev. ODZ2; TNM2; Ten-M2; Odz, Odd Oz/Ten-M Homolog 2 (Drosophila); Protein Odd Oz/Ten-M Homolog 2; Odz, Odd Oz/Ten-M Homolog 2; Tenascin-M2; Odd Oz/Ten-M Homolog 2; Teneurin-2; Neurestin Alpha; KIAA1127; Teneurin Transmembrane Protein 2; Ten

  • AA Sequence

    GLNWQLQPADGHTFNNGIRTGLPGNDDVATMPSGGKVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCN

  • Predicted Molecular Mass

    48.5 kDa

  • Molecular Weight

    Approximately 55-65 kDa & 38-43 kDa & 25-30 kDa, based on SDS-PAGE under reducing conditions.

  • Glycosylation

    Yes

  • Purity

    ≥ 90%, as determined by reducing Bis-Tris PAGE.

Product Properties

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, 2mM DTT, pH 7.4, 8% trehalose.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

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