PLEKHA4 - pleckstrin homology domain containing A4 Gene

Also Known as PEPP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57664

About PLEKHA4

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,837,097-48,868,617 (from NCBI)

This gene has 11 transcripts (splice variants), 164 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 7.2), endometrium (RPKM 6.0) and 24 other tissues.

Summary

This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

PLEKHA4 Products (2)

mRNA Protein Name
NM_001161354.2 NP_001154826.1 pleckstrin homology domain-containing family A member 4 isoform 2
NM_020904.3 NP_065955.2 pleckstrin homology domain-containing family A member 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
31091453 GOA
enables phosphatidylinositol-3,5-bisphosphate binding IDA
IDA: Inferred from direct assay
31091453 GOA
enables phosphatidylinositol-3-phosphate binding IDA
IDA: Inferred from direct assay
11001876 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
31091453 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
29433439 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
31091453 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
31091453 GOA
Cellular Component GO Annotation Evidence References Source
located in extrinsic component of cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
31091453 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHA4 Protein Structure

PH

PH: PH domain (56 - 152)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family A member 4

  • PH domain-containing family A member 4

PLEKHA4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810314 PLEKHA4(N-term) Antibody WB, IHC-P, FC Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10681 PLEKHA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PLEKHA4 VGNC VGNC:76027
Felis catus PLEKHA4 VGNC VGNC:64218
Bos taurus PLEKHA4 VGNC VGNC:33006
Mus musculus PLEKHA4 MGD MGI:1916467
Rattus norvegicus PLEKHA4 RGD RGD:735133
Canis familiaris PLEKHA4 VGNC VGNC:53751
Others PLEKHA4 NCBI