2. Gene
  3. Cldn10 - claudin 10 Gene

Cldn10 - claudin 10 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cldn10a; Cldn10b; D14Ertd728e; 6720456I16Rik

Gene ID: 58187 | Gene type: protein coding

About Cldn10

Summary

This intronless gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight unction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Six alternatively spliced transcript variants have been identified, which encode different isoforms with distinct electric charge of the first extracellular loop and with or without the fourth transmembrane region. These isoforms exhibit distinct localization and function in paracellular anion or cation permeability. [provided by RefSeq, Aug 2010]

Cldn10 Products(6)

mRNA Protein Name
NM_001160096.1 NP_001153568.1 claudin-10 isoform a_i1
NM_001160097.1 NP_001153569.1 claudin-10 isoform a_i2
NM_001160098.1 NP_001153570.1 claudin-10 isoform a_i3
NM_001160099.1 NP_001153571.1 claudin-10 isoform b_i1 precursor
NM_021386.4 NP_067361.2 claudin-10 isoform b precursor
NM_023878.3 NP_076367.2 claudin-10 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables paracellular tight junction channel activity IDA
IDA: Inferred from direct assay
19383724 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19706394 MGI
Biological Process GO Annotation Evidence Reference Source
involved in paracellular transport IDA
IDA: Inferred from direct assay
19383724 MGI
Cellular Component GO Annotation Evidence Reference Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
16520537 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
18757308 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
19383724 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18757308 MGI
located in tight junction IDA
IDA: Inferred from direct assay
19383724 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-10

claudin 10B

claudin-10A

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02763 CLDN10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn10 NCBI NCBI:9071