2. Gene
  3. WFDC1 - WAP four-disulfide core domain 1 Gene

WFDC1 - WAP four-disulfide core domain 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PS20

Gene ID: 58189 | Gene type: protein coding

About WFDC1

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,294,878-84,329,844 (from NCBI)

This gene has 5 transcripts (splice variants) and 193 orthologues. Biased expression in placenta (RPKM 49.5), prostate (RPKM 33.0) and 13 other tissues.

Summary

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many Cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus Infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

WFDC1 Products(3)

mRNA Protein Name
NM_001282466.2 NP_001269395.1 WAP four-disulfide core domain protein 1 isoform 1 precursor
NM_001282467.2 NP_001269396.1 WAP four-disulfide core domain protein 1 isoform 2 precursor
NM_021197.4 NP_067020.2 WAP four-disulfide core domain protein 1 isoform 1 precursor

WFDC1 Protein Structure

WAP

WAP: WAP-type (Whey Acidic Protein) 'four-disulfide core' (63 - 106)

  • 0
  • 100
  • 200
  • 220 a.a.
Protein Preferred Names Protein Names

WAP four-disulfide core domain protein 1

WAP four-disulfide core domain 1 homolog

Recombinant WFDC1 Proteins

Cat. No. Product Name Accession Purity
HY-P78024 WFDC1/PS20 Protein, Human (His) Q9HC57 (K32-Q220) ≥95%

Related Diseases

Diseases Alias
Corneal Staphyloma

Staphyloma Of Cornea

Congenital Staphyloma
Ocular Hypotension

Hypotony Of Eye
Myopathy, Distal, 1

Laing Distal Myopathy

Laing Early-Onset Distal Myopathy

MPD1

Distal Myopathy 1

Myopathy, Distal, Early-Onset, Autosomal Dominant

Distal Myopathy Type 1

Gowers Disease

Myopathy, Late Distal Hereditary

Myopathy Distal, Type 1

Myopathy Distal Early-Onset Autosomal Dominant

Myopathy Late Distal Hereditary

Myopathy, Distal, Type 1

Welander Distal Myopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15809 WFDC1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus WFDC1 VGNC VGNC:107028
Canis familiaris WFDC1 VGNC VGNC:48404
Mus musculus WFDC1 MGD MGI:1915116
Macaca mulatta WFDC1 VGNC VGNC:78973
Rattus norvegicus WFDC1 RGD RGD:68938
Macaca fascicularis WFDC1 NCBI
Others WFDC1 NCBI