Fkbp1b - FKBP prolyl isomerase 1B Gene

Also Known as FKBP-1B; FKBP-12.6

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58950

Summary

Enables FK506 binding activity and cyclic nucleotide binding activity. Involved in several processes, including positive regulation of axon regeneration; response to hydrogen peroxide; and response to vitamin E. Located in intracellular membrane-bounded organelle. Biomarker of cardiomyopathy and congestive heart failure. Human ortholog(s) of this gene implicated in Graves' disease. Orthologous to human FKBP1B (FKBP prolyl isomerase 1B). [provided by Alliance of Genome Resources, Apr 2022]

Fkbp1b Products (3)

mRNA Protein Name
NM_001401262.1 NP_001388191.1 peptidyl-prolyl cis-trans isomerase FKBP1B isoform 2
NM_001401263.1 NP_001388192.1 peptidyl-prolyl cis-trans isomerase FKBP1B isoform 3
NM_022675.2 NP_073166.1 peptidyl-prolyl cis-trans isomerase FKBP1B isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables FK506 binding IDA
IDA: Inferred from direct assay
9013543 RGD
enables cyclic nucleotide binding IDA
IDA: Inferred from direct assay
9013543 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of axon regeneration IDA
IDA: Inferred from direct assay
9512405 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
9013543 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
18611397 RGD
involved in response to vitamin E IEP
IEP: Inferred from expression pattern
18611397 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase FKBP1B

  • 12.6 kDa FK506-binding protein

  • 12.6 kDa FKBP

  • FK506-binding protein 1B

  • PPIase FKBP1B

  • calstabin-2

  • immunophilin FKBP12.6

  • rotamase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04961 FKBP1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fkbp1b NCBI NCBI:2281