Myoz1 - myozenin 1 Gene

Mus musculus

Also known as FATZ; Myoz; 2310001N11Rik

Gene ID: 59011 | Gene type: protein coding

About Myoz1

Summary

Enables protein serine/threonine Phosphatase Inhibitor activity. Involved in several processes, including negative regulation of calcineurin-NFAT signaling cascade; negative regulation of skeletal muscle tissue regeneration; and sarcomere organization. Acts upstream of or within with a positive effect on skeletal muscle fiber adaptation. Located in actin Cytoskeleton. Is expressed in diaphragm; heart; musculature; and tongue. Orthologous to human MYOZ1 (myozenin 1). [provided by Alliance of Genome Resources, Apr 2022]

Myoz1 Products(1)

mRNA	Protein	Name
NM_021508.3	NP_067483.1	myozenin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11114196	MGI
enables protein serine/threonine phosphatase inhibitor activity	IMP IMP: Inferred from mutant phenotype	18846255	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	18846255	MGI
involved in negative regulation of skeletal muscle tissue regeneration	IMP IMP: Inferred from mutant phenotype	18846255	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18846255	MGI
involved in sarcomere organization	IMP IMP: Inferred from mutant phenotype	18846255	MGI
acts upstream of or within positive effect skeletal muscle fiber adaptation	IMP IMP: Inferred from mutant phenotype	18846255	MGI
involved in skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	18846255	MGI
involved in wound healing	IMP IMP: Inferred from mutant phenotype	18846255	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	11114196	MGI
located in actin cytoskeleton	IPI IPI: Inferred from physical interaction	11114196	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myozenin-1

calcineurin-2	calsarcin-2
filamin-, actinin- and telethonin-binding protein	skeletal muscle-specific protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08965	MYOZ1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Myoz1	NCBI	NCBI:58529

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