Asl - argininosuccinate lyase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59085

Summary

Enables argininosuccinate lyase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to organic cyclic compound; and response to peptide hormone. Located in several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase). [provided by Alliance of Genome Resources, Apr 2022]

Asl Products (1)

mRNA Protein Name
NM_021577.3 NP_067588.2 argininosuccinate lyase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables argininosuccinate lyase activity IDA
IDA: Inferred from direct assay
4062872 RGD
Biological Process GO Annotation Evidence References Source
involved in argininosuccinate metabolic process IDA
IDA: Inferred from direct assay
4062872 RGD
involved in cellular response to ammonium ion IEP
IEP: Inferred from expression pattern
10353334 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
11097477 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
8923475 RGD
involved in cellular response to glucagon stimulus IEP
IEP: Inferred from expression pattern
8387274 RGD
involved in cellular response to glucocorticoid stimulus IEP
IEP: Inferred from expression pattern
11097477 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
11097477 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
11072090 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
11072090 RGD
involved in diaphragm development IEP
IEP: Inferred from expression pattern
9618389 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
10473900 RGD
involved in liver development IDA
IDA: Inferred from direct assay
9535537 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
10473900 RGD
involved in midgut development IEP
IEP: Inferred from expression pattern
9544996 RGD
involved in response to amine IEP
IEP: Inferred from expression pattern
16168957 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
9688877 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
8576237 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
2547341 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
8387274 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
9688877 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
20452409 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
9535537 RGD
involved in response to zinc ion IEP
IEP: Inferred from expression pattern
11686772 RGD
involved in urea cycle IDA
IDA: Inferred from direct assay
4062872 RGD
Cellular Component GO Annotation Evidence References Source
located in cell body fiber IDA
IDA: Inferred from direct assay
12445581 RGD
located in mitochondrial outer membrane IDA
IDA: Inferred from direct assay
8867809 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12445581 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
17900569 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15199240 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

argininosuccinate lyase

  • ASAL

  • arginosuccinase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0451A Dopamine hydrochloride Inhibitor 99.79% Unkown
HY-B0451 Dopamine Inhibitor 98.56% Unkown

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113284 Succinyladenosine 99.43% Unkown
HY-B0451AS4 Dopamine-d3 hydrochloride 99.88% Unkown
HY-B0451AS7 Dopamine-d5 hydrochloride Inhibitor 99.6% Unkown
HY-B0451AS Dopamine-d4 hydrochloride 99.99% Unkown
HY-B0451AS1 Dopamine-13C6 hydrochloride 98.71% Unkown
HY-B0451AS5 Dopamine-13C hydrochloride 99.74% Unkown
HY-RS01095 ASL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0451AS6 Dopamine-13C,15N hydrochloride 99.02% Unkown
HY-B0451AS2 Dopamine-d2 hydrochloride 99.6% Unkown
HY-B0451AS3 Dopamine-d2-1 hydrochloride / Unkown
HY-RS00418 ADSL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W752476 Succinyladenosine-13C4 / Unkown
HY-RS16982 Asl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18123 Adsl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23425 Asl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W416440 Esmolol acid hydrochloride Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asl NCBI NCBI:435