2. Gene
  3. Jph2 - junctophilin 2 Gene

Jph2 - junctophilin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Jp2; JP-2; 1110002E14Rik

Gene ID: 59091 | Gene type: protein coding

About Jph2

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and core promoter sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of cardiac muscle tissue development. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Located in several cellular components, including Z disc; nucleus; and sarcoplasmic reticulum. Part of junctional membrane complex. Is expressed in heart; lung; skeletal muscle; and stomach. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy 17. Orthologous to human JPH2 (junctophilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Jph2 Products(2)

mRNA Protein Name
NM_001205076.1 NP_001192005.1 junctophilin-2
NM_021566.2 NP_067541.1 junctophilin-2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
30409805 MGI
enables core promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
30409805 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15541368 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
30409805 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
30409805 MGI
acts upstream of or within positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
10949023 MGI
involved in regulation of cardiac muscle tissue development IMP
IMP: Inferred from mutant phenotype
10949023 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Z disc IDA
IDA: Inferred from direct assay
10949023 MGI
part of junctional membrane complex IMP
IMP: Inferred from mutant phenotype
10949023 MGI
located in membrane IDA
IDA: Inferred from direct assay
15541368 MGI
located in nucleus IDA
IDA: Inferred from direct assay
30409805 MGI
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
10949023 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

junctophilin-2

junctophilin type 2

Jph2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Jph2 Q9ET78 TRPC3 Oryctolagus cuniculus G1U2U3
Anti Bait CoIP
19277847
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07046 JPH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jph2 NCBI NCBI:57158