RBP1 - retinol binding protein 1 Gene

Also Known as CRBP; RBPC; CRBP1; CRBPI; CRABP-I

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5947

About RBP1

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:139,517,438-139,539,742 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 15 paralogues. Biased expression in ovary (RPKM 127.5), adrenal (RPKM 41.0) and 6 other tissues.

Summary

This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

RBP1 Products (4)

mRNA	Protein	Name
NM_001130992.3	NP_001124464.1	retinol-binding protein 1 isoform b
NM_001130993.3	NP_001124465.1	retinol-binding protein 1 isoform c
NM_001365940.2	NP_001352869.1	retinol-binding protein 1 isoform d
NM_002899.5	NP_002890.2	retinol-binding protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables all-trans-retinol binding	IDA IDA: Inferred from direct assay	28057518	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	15632377	GOA
involved in vitamin A metabolic process	IMP IMP: Inferred from mutant phenotype	15632377	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in lipid droplet	IDA IDA: Inferred from direct assay	15632377	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBP1 Protein Structure

Lipocalin

0
100
197 a.a.

Protein Preferred Names	Protein Names
retinol-binding protein 1	cellular retinol binding protein 1

RBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RBP1	P09455	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
Intra	RBP1	P09455	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	RBP1	P09455	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	RBP1	P09455	UBE2J2	Homo sapiens	Q8N2K1	Y2H Prey Pooling	32296183
Intra	RBP1	P09455	UBE2J2	Homo sapiens	Q8N2K1	Validated Y2H	32296183
Intra	RBP1	P09455	UBE2J2	Homo sapiens	Q8N2K1	Y2H Array	32296183
Intra	RBP1	P09455	DHPS	Homo sapiens	P49366	Validated Y2H	32296183
Intra	RBP1	P09455	TTC19	Homo sapiens	Q6DKK2	Y2H Array	32296183
Intra	RBP1	P09455	TTC19	Homo sapiens	Q6DKK2	Y2H Prey Pooling	32296183
Intra	RBP1	P09455	TTC19	Homo sapiens	Q6DKK2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RBP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71093	RBP1 Protein, Human	P09455 (P2-Q135)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Blepharophimosis
Endometrial Hyperplasia
Epicanthus
Microphthalmia, Syndromic 9	Matthew-Wood Syndrome Spear Syndrome Anophthalmia/Microphthalmia And Pulmonary Hypoplasia Microphthalmia, Isolated, With Coloboma 8 MCOPS9 Anophthalmia, Clinical, With Mild Facial Dysmorphism And Variable Malformations Of The Lung, Heart, And Diaphragm Pulmonary Hypoplasia-Diaphragmatic Hernia-Anophthalmia-Cardiac Defect Pdac Pulmonary Agenesis, Microphthalmia, And Diaphragmatic Defect Pmd Syndromic Microphthalmia 9 Anophthalmia-Pulmonary Hypoplasia Syndrome Clinical Anophthalmia Mild Facial Dysmorphism Lung Heart And Diaphragm Malformations Pulmonary Agenesis Microphthalmi And Diaphragmatic Defect Microphthalmia Syndromic 9 Matthew Wood Syndrome Pdac Syndrome Pulmonary Hypoplasia-Diaphragmatic Hernia-Anophthalmia-Cardiac Defect Syndrome Microphthalmia, Isolated, With Coloboma, 8 MCOPCB8 Isolated Colobomatous Microphthalmia 8 Microphthalmia, Syndromic, 9 Anophthalmia With Pulmonary Hypoplasia Microphthalmia Syndromic, Type 9 Anophthalmia And Pulmonary Hypoplasia
Keratoacanthoma	Ka - [Keratoacanthoma] Well-Differentiated Squamous Cell Carcinoma
Hypervitaminosis A	Hypervitaminosis A, Susceptibility To Hyperalimentation Of Vitamin A
Xerophthalmia	Conjunctival Xerosis
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Syndromic Microphthalmia	Microphthalmia, Syndromic
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Dowling-Degos Disease 1	Reticular Pigment Anomaly Of Flexures DDD1 Ddd Hyperpigmentation Dowling-Degos Disease
Diaphragmatic Hernia, Congenital	Congenital Diaphragmatic Hernia Diaphragmatic Hernia Cdh Congenital Diaphragmatic Defect Hernia, Diaphragmatic Dih Hernia, Congenital Diaphragmatic Hcd Diaphragmatic Defect, Congenital Diaphragm, Unilateral Agenesis Of Hemidiaphragm, Agenesis Of Diaphragmatic Hernia 1 Agenesis Of Hemidiaphragm Unilateral Agenesis Of Diaphragm Hernia Diaphragmatic Hernia Diaphragmatic Congenital Hernia, Diaphragmatic, Type 1 Hiatus Hernia Oesophageal Hiatus Hernia Paraoesophageal Hernia Sliding Hiatus Hernia Congenital Diaphragm Hernia Congenital Diaphragm Defect With Hernia Gross Congenital Diaphragm Defect
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00971	ARID4A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11766	RBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18256	Rbp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24736	Rbp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25117	Pdxp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RBP1	VGNC	VGNC:76688
Rattus norvegicus	RBP1	RGD	RGD:3543
Bos taurus	RBP1	VGNC	VGNC:33812
Mus musculus	RBP1	MGD	MGI:97876
Canis familiaris	RBP1	VGNC	VGNC:59058
Felis catus	RBP1	VGNC	VGNC:102811
Others	RBP1	NCBI