REG1B - regenerating family member 1 beta Gene

Also Known as REGH; REGL; PSPS2; REGI-BETA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5968

About REG1B

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:79,085,023-79,087,993 (from NCBI)

This gene has 5 transcripts (splice variants), 934 orthologues and 5 paralogues. Biased expression in duodenum (RPKM 280.8), small intestine (RPKM 149.9) and 2 other tissues.

Summary

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

REG1B Products (1)

mRNA Protein Name
NM_006507.4 NP_006498.1 lithostathine-1-beta precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REG1B Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (54 - 163)

  • 0
  • 100
  • 166 a.a.
Protein Preferred Names Protein Names

lithostathine-1-beta

  • PSP-2

REG1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
REG1B P48304 REG1A Homo sapiens P05451
Anti Tag CoIP
28514442
Intra
REG1B P48304 REG1A Homo sapiens P05451
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant REG1B Proteins

Cat. No. Product Name Accession Purity
HY-P76565 REG-1 beta/REG1B Protein, Human (HEK293, His) P48304 (Q23-N166) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pancreatitis

  • Mumps Pancreatitis
Anaerobic Pneumonia

  • Pneumonia Due To Anaerobes
Amebiasis

  • Amoebiasis

  • Entamoebiasis

  • Chronic Intestinal Amebiasis

  • Amoebiasis, Unspecified

  • Amebic Colitis

  • Amoebic Enteritis

  • Infection Due To Entamoeba Histolytica

  • Amoebic Infection

  • Disease Due To Endamoebidae

  • Amoebiasis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11819 REG1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Others REG1B NCBI