BCL7A - BAF chromatin remodeling complex subunit BCL7A Gene

Also Known as BCL7; SMARCJ1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 605

About BCL7A

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,021,884-122,062,044 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 222 orthologues, 2 paralogues and is associated with 56 phenotypes. Ubiquitous expression in brain (RPKM 10.8), lymph node (RPKM 10.6) and 25 other tissues.

Summary

This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BCL7A Products (2)

mRNA Protein Name
NM_001024808.3 NP_001019979.1 B-cell CLL/lymphoma 7 protein family member A isoform b
NM_020993.5 NP_066273.1 B-cell CLL/lymphoma 7 protein family member A isoform a

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
part of SWI/SNF complex IDA
IDA: Inferred from direct assay
23644491 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL7A Protein Structure

BCL_N

BCL_N: BCL7, N-terminal conserver region (4 - 52)

  • 0
  • 100
  • 200
  • 210 a.a.
Protein Preferred Names Protein Names

B-cell CLL/lymphoma 7 protein family member A

  • B-cell CLL/lymphoma 7A

BCL7A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BCL7A Q4VC05 ALAS1 Homo sapiens P13196
Y2H Prey Pooling
25416956
Intra
BCL7A Q4VC05 ALAS1 Homo sapiens P13196
Validated Y2H
25416956
Intra
BCL7A Q4VC05 ALAS1 Homo sapiens P13196
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
B-Cell Non-Hodgkin Lymphoma

  • B-Cell Nhl

  • B-Cell Non-Hodgkins Lymphoma
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
Burkitt Lymphoma

  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma
Williams-Beuren Syndrome

  • Williams Syndrome

  • WBS

  • Wms

  • Deletion 7q11.23

  • Monosomy 7q11.23

  • Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

  • Fanconi Schlesinger Syndrome

  • Beuren Syndrome

  • Elfin Facies Syndrome

  • Elfin Facies With Hypercalcemia

  • Hypercalcemia-Supravalvar Aortic Stenosis

  • Ws
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01440 BCL7A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BCL7A VGNC VGNC:107696
Canis familiaris BCL7A VGNC VGNC:38412
Bos taurus BCL7A VGNC VGNC:53891
Mus musculus BCL7A MGD MGI:1924295
Macaca mulatta BCL7A VGNC VGNC:70038
Rattus norvegicus BCL7A RGD RGD:1585128
Others BCL7A NCBI