Syt11 - synaptotagmin 11 Gene

Rattus norvegicus

Gene ID: 60568 | Gene type: protein coding

About Syt11

Summary

Predicted to enable several functions, including beta-tubulin binding activity; phosphatidylserine binding activity; and ubiquitin protein Ligase binding activity. Involved in negative regulation of cellular component organization and negative regulation of dopamine secretion. Located in several cellular components, including inhibitory synapse; presynaptic active zone membrane; and synaptic vesicle. Is active in Schaffer collateral - CA1 synapse and postsynapse. Is integral component of presynaptic active zone membrane and integral component of synaptic vesicle membrane. Orthologous to human SYT11 (synaptotagmin 11). [provided by Alliance of Genome Resources, Apr 2022]

Syt11 Products(1)

mRNA	Protein	Name
NM_031667.3	NP_113855.2	synaptotagmin-11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables calcium ion binding	IDA IDA: Inferred from direct assay	9162066	RGD
NOT enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	9162066	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	30021165	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of clathrin coat assembly	IMP IMP: Inferred from mutant phenotype	26589353	RGD
involved in negative regulation of clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	26589353	RGD
involved in negative regulation of dopamine secretion	IDA IDA: Inferred from direct assay	29311685	RGD
involved in negative regulation of endocytosis	IDA IDA: Inferred from direct assay	29311685	RGD
involved in negative regulation of membrane invagination	IMP IMP: Inferred from mutant phenotype	26589353	RGD
involved in negative regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	26589353	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	22960622	RGD
located in axon	IDA IDA: Inferred from direct assay	22960622	RGD
located in cell body	IDA IDA: Inferred from direct assay	26589353	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	22960622	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	22960622	RGD
located in inhibitory synapse	IDA IDA: Inferred from direct assay	22960622	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	12925569	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12925569	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	22960622	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	22960622	RGD
located in presynapse	IDA IDA: Inferred from direct assay	22960622	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	22960622	RGD
located in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	22960622	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	22960622	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	22960622	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	12925569	RGD
located in vesicle	IDA IDA: Inferred from direct assay	26589353	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptotagmin-11

synaptotagmin XI

sytXI

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14108	SYT11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14109	SYT12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Syt11	NCBI	NCBI:23208

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