Syt11 - synaptotagmin 11 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60568

Summary

Predicted to enable several functions, including beta-tubulin binding activity; phosphatidylserine binding activity; and ubiquitin protein Ligase binding activity. Involved in negative regulation of cellular component organization and negative regulation of dopamine secretion. Located in several cellular components, including inhibitory synapse; presynaptic active zone membrane; and synaptic vesicle. Is active in Schaffer collateral - CA1 synapse and postsynapse. Is integral component of presynaptic active zone membrane and integral component of synaptic vesicle membrane. Orthologous to human SYT11 (synaptotagmin 11). [provided by Alliance of Genome Resources, Apr 2022]

Syt11 Products (1)

mRNA Protein Name
NM_031667.3 NP_113855.2 synaptotagmin-11

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables calcium ion binding IDA
IDA: Inferred from direct assay
9162066 RGD
NOT enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
9162066 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
30021165 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of clathrin coat assembly IMP
IMP: Inferred from mutant phenotype
26589353 RGD
involved in negative regulation of clathrin-dependent endocytosis IMP
IMP: Inferred from mutant phenotype
26589353 RGD
involved in negative regulation of dopamine secretion IDA
IDA: Inferred from direct assay
29311685 RGD
involved in negative regulation of endocytosis IDA
IDA: Inferred from direct assay
29311685 RGD
involved in negative regulation of membrane invagination IMP
IMP: Inferred from mutant phenotype
26589353 RGD
involved in negative regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
26589353 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
22960622 RGD
located in axon IDA
IDA: Inferred from direct assay
22960622 RGD
located in cell body IDA
IDA: Inferred from direct assay
26589353 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
22960622 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
22960622 RGD
located in inhibitory synapse IDA
IDA: Inferred from direct assay
22960622 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
12925569 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12925569 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
22960622 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
22960622 RGD
located in presynapse IDA
IDA: Inferred from direct assay
22960622 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
22960622 RGD
located in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
22960622 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
22960622 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
22960622 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
12925569 RGD
located in vesicle IDA
IDA: Inferred from direct assay
26589353 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptotagmin-11

  • synaptotagmin XI

  • sytXI

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14108 SYT11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14109 SYT12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syt11 NCBI NCBI:23208