Trim71 - tripartite motif-containing 71 Gene

Also Known as Lin41; Gm1127; lin-41; mLin41; mlin-41; 2610206G21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 636931

Summary

Enables miRNA binding activity and ubiquitin protein Ligase activity. Involved in several processes, including miRNA metabolic process; protein autoubiquitination; and regulation of gene expression. Acts upstream of or within several processes, including neural tube closure; positive regulation of gene silencing by miRNA; and regulation of protein metabolic process. Located in P-body. Is expressed in several structures, including dorsal root ganglion; ileum; limb bud; male reproductive gland or organ; and tail. Orthologous to human TRIM71 (tripartite motif containing 71). [provided by Alliance of Genome Resources, Apr 2022]

Trim71 Products (1)

mRNA	Protein	Name
NM_001042503.2	NP_001035968.1	E3 ubiquitin-protein ligase TRIM71

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables miRNA binding	IDA IDA: Inferred from direct assay	22735451	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19898466	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	19898466	MGI
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	22508726	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22735451	MGI
involved in fibroblast growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22508726	MGI
involved in miRNA-mediated gene silencing by inhibition of translation	IMP IMP: Inferred from mutant phenotype	22735451	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	19098426	MGI
involved in neural tube development	IDA IDA: Inferred from direct assay	22508726	MGI
acts upstream of or within positive regulation of miRNA-mediated gene silencing	IDA IDA: Inferred from direct assay	19898466	MGI
acts upstream of or within positive regulation of miRNA-mediated gene silencing	IMP IMP: Inferred from mutant phenotype	19898466	MGI
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	22508726	MGI
acts upstream of or within regulation of miRNA-mediated gene silencing	IGI IGI: Inferred from genetic interaction	19898466	MGI
involved in regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	22508726	MGI
acts upstream of or within regulation of protein metabolic process	IDA IDA: Inferred from direct assay	19898466	MGI
involved in stem cell proliferation	IMP IMP: Inferred from mutant phenotype	22735451	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	19898466	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase TRIM71	RING-type E3 ubiquitin transferase TRIM71 lin-41 homolog protein lin-41 homolog tripartite motif-containing protein 71

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15070	TRIM71 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trim71	NCBI	NCBI:131405