Kcne3 - potassium voltage-gated channel subfamily E regulatory subunit 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 63883

Summary

Enables Potassium Channel regulator activity and transmembrane transporter binding activity. Involved in negative regulation of delayed rectifier Potassium Channel activity and positive regulation of voltage-gated Calcium Channel activity. Located in plasma membrane. Human ortholog(s) of this gene implicated in Brugada syndrome 6 and hypokalemic periodic paralysis. Orthologous to human KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3). [provided by Alliance of Genome Resources, Apr 2022]

Kcne3 Products (1)

mRNA Protein Name
NM_022235.2 NP_071571.1 potassium voltage-gated channel subfamily E member 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
11426298 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
21911611 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
12954870 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of delayed rectifier potassium channel activity IDA
IDA: Inferred from direct assay
12954870 RGD
involved in negative regulation of voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
14679187 RGD
involved in positive regulation of voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
14679187 RGD
involved in regulation of potassium ion transport IMP
IMP: Inferred from mutant phenotype
11426298 RGD
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12954870 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
12954870 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily E member 3

  • minimum potassium ion channel-related peptide 2

  • mink-related peptide 2

  • potassium channel subunit beta MiRP2

  • potassium channel, voltage gated subfamily E regulatory beta subunit 3

  • potassium channel, voltage-gated Isk-related subfamily E regulatory beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-142991 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol / Unkown
HY-RS07117 KCNE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcne3 NCBI NCBI:10008