Lrat - lecithin retinol acyltransferase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64047

Summary

Enables phosphatidylcholine-retinol O-acyltransferase activity; retinoic acid binding activity; and retinol binding activity. Involved in response to retinoic acid; response to vitamin A; and retinoid metabolic process. Located in multivesicular body; perinuclear region of cytoplasm; and rough endoplasmic reticulum. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol Acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Lrat Products (1)

mRNA Protein Name
NM_022280.3 NP_071616.1 lecithin retinol acyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylcholine-retinol O-acyltransferase activity IDA
IDA: Inferred from direct assay
2253789 RGD
enables retinoic acid binding IDA
IDA: Inferred from direct assay
8460936 RGD
enables retinol binding IDA
IDA: Inferred from direct assay
2253789 RGD
Biological Process GO Annotation Evidence References Source
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
19700416 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
19700416 RGD
involved in retinol metabolic process IDA
IDA: Inferred from direct assay
2253789 RGD
Cellular Component GO Annotation Evidence References Source
located in multivesicular body IDA
IDA: Inferred from direct assay
18544127 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18544127 RGD
located in rough endoplasmic reticulum IDA
IDA: Inferred from direct assay
18544127 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lecithin retinol acyltransferase

  • lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)

  • phosphatidylcholine--retinol O-acyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07776 LRAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169085 LRAT-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrat NCBI NCBI:9227