LHPP - phospholysine phosphohistidine inorganic pyrophosphate phosphatase Gene

Homo sapiens

Also known as HDHD2B

Gene ID: 64077 | Gene type: protein coding

About LHPP

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:124,461,823-124,614,141 (from NCBI)

This gene has 9 transcripts (splice variants), 196 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 7.5), kidney (RPKM 4.5) and 25 other tissues.

Summary

Enables inorganic diphosphatase activity and protein homodimerization activity. Involved in phosphate-containing compound metabolic process. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

LHPP Products(4)

mRNA	Protein	Name
NM_001167880.2	NP_001161352.1	phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform 2
NM_001318331.2	NP_001305260.1	phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform 3
NM_001318332.2	NP_001305261.1	phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform 4
NM_022126.4	NP_071409.3	phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform 1

LHPP Protein Structure

Hydrolase_6

Hydrolase_like

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

hLHPP

Recombinant LHPP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71632	LHPP Protein, Human (His-SUMO)	Q9H008 (M1-K270)	≥95%

Related Diseases

Diseases

Alias

Melancholia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07630	LHPP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LHPP	VGNC	VGNC:42661
Mus musculus	LHPP	MGD	MGI:1923679
Macaca mulatta	LHPP	VGNC	VGNC:74164
Rattus norvegicus	LHPP	RGD	RGD:1359187
Bos taurus	LHPP	VGNC	VGNC:30870
Felis catus	LHPP	VGNC	VGNC:63223
Others	LHPP	NCBI