LHPP - phospholysine phosphohistidine inorganic pyrophosphate phosphatase Gene

Also Known as HDHD2B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64077

About LHPP

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:124,461,823-124,614,141 (from NCBI)

This gene has 9 transcripts (splice variants), 196 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 7.5), kidney (RPKM 4.5) and 25 other tissues.

Summary

Enables inorganic diphosphatase activity and protein homodimerization activity. Involved in phosphate-containing compound metabolic process. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

LHPP Products (4)

mRNA Protein Name
NM_001167880.2 NP_001161352.1 phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform 2
NM_001318331.2 NP_001305260.1 phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform 3
NM_001318332.2 NP_001305261.1 phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform 4
NM_022126.4 NP_071409.3 phospholysine phosphohistidine inorganic pyrophosphate phosphatase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables inorganic diphosphate phosphatase activity IDA
IDA: Inferred from direct assay
12801912 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
12801912 GOA
Biological Process GO Annotation Evidence References Source
involved in phosphate-containing compound metabolic process IDA
IDA: Inferred from direct assay
12801912 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
16430861 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16430861 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LHPP Protein Structure

Hydrolase_6

Hydrolase_6: Haloacid dehalogenase-like hydrolase (14 - 112)

Hydrolase_like

Hydrolase_like: HAD-hyrolase-like (187 - 260)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

  • hLHPP

Recombinant LHPP Proteins

Cat. No. Product Name Accession Purity
HY-P71632 LHPP Protein, Human (His-SUMO) Q9H008-1 (M1-K270) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Melancholia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07630 LHPP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18138 Lhpp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24613 Lhpp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LHPP VGNC VGNC:42661
Mus musculus LHPP MGD MGI:1923679
Macaca mulatta LHPP VGNC VGNC:74164
Rattus norvegicus LHPP RGD RGD:1359187
Bos taurus LHPP VGNC VGNC:30870
Felis catus LHPP VGNC VGNC:63223
Others LHPP NCBI