MS4A6A - membrane spanning 4-domains A6A Gene

Also Known as CDA01; MS4A6; 4SPAN3; CD20L3; MST090; MSTP090; 4SPAN3.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64231

About MS4A6A

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:60,171,607-60,184,666 (from NCBI)

This gene has 21 transcripts (splice variants), 362 orthologues and 16 paralogues. Broad expression in lymph node (RPKM 27.7), spleen (RPKM 26.2) and 22 other tissues.

Summary

This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011]

MS4A6A Products (5)

mRNA Protein Name
NM_001247999.2 NP_001234928.1 membrane-spanning 4-domains subfamily A member 6A isoform 4
NM_001330275.1 NP_001317204.1 membrane-spanning 4-domains subfamily A member 6A isoform 5
NM_022349.4 NP_071744.2 membrane-spanning 4-domains subfamily A member 6A isoform 2
NM_152851.2 NP_690590.1 membrane-spanning 4-domains subfamily A member 6A isoform 3
NM_152852.3 NP_690591.1 membrane-spanning 4-domains subfamily A member 6A isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in trans-Golgi network IDA
IDA: Inferred from direct assay
23874341 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MS4A6A Protein Structure

CD20

CD20: CD20-like family (47 - 208)

  • 0
  • 100
  • 200
  • 248 a.a.
Protein Preferred Names Protein Names

membrane-spanning 4-domains subfamily A member 6A

  • CD20 antigen-like 3

MS4A6A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MS4A6A Q9H2W1 GPRC5D Homo sapiens Q9NZD1
Y2H Prey Pooling
32296183
Intra
MS4A6A Q9H2W1 GPRC5D Homo sapiens Q9NZD1
Validated Y2H
32296183
Intra
MS4A6A Q9H2W1 GPRC5D Homo sapiens Q9NZD1
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

  • Nasu-Hakola Disease

  • Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

  • Plosl

  • Nhd

  • Presenile Dementia With Bone Cysts

  • Plo-Sl

  • PLOSL1

  • Dementia, Prefrontal, With Bone Cysts

  • Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease

  • Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

  • Brain-Bone-Fat Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08704 MS4A6A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MS4A6A RGD RGD:1305800
Macaca mulatta MS4A6A VGNC VGNC:101361
Others MS4A6A NCBI