XPO4 - exportin 4 Gene
Also Known as exp4
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 64328
About XPO4
Cytogenetic location: 13q12.11
Genomic coordinates (GRCh38): 13:20,777,329-20,902,774 (from NCBI)
This gene has 3 transcripts (splice variants), 219 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 3.0), heart (RPKM 2.8) and 25 other tissues.
Summary
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and Other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]
XPO4 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001372061.1 | NP_001358990.1 | exportin-4 isoform 2 |
| NM_022459.5 | NP_071904.4 | exportin-4 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables nuclear export signal receptor activity |
IDA
IDA: Inferred from direct assay
|
10944119 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
10944119 | GOA |
| enables small GTPase binding |
IDA
IDA: Inferred from direct assay
|
10944119 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of protein export from nucleus |
IMP
IMP: Inferred from mutant phenotype
|
16449645 | GOA |
| involved in protein export from nucleus |
IDA
IDA: Inferred from direct assay
|
10944119 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| is active in nucleus |
IDA
IDA: Inferred from direct assay
|
10944119 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
XPO4 Protein Structure
CRM1_C
CRM1_C: CRM1 C terminal (961 - 1071)
- 0
- 200
- 400
- 600
- 800
- 1000
- 1151 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
exportin-4 |
|
XPO4 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P83040 | XPO4 Antibody (YA2785) | WB | Human, Mouse, Rat |
| HY-P83040A | XPO4 Antibody (YA2785)(PBS only) | WB | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Enamel Erosion |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS15890 | XPO4 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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