LIPN - lipase family member N Gene

Homo sapiens

Also known as LI4; ARCI8; LIPL4; bA186O14.3

Gene ID: 643418 | Gene type: protein coding

About LIPN

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:88,757,226-88,779,626 (from NCBI)

This gene has 2 transcripts (splice variants), 155 orthologues, 5 paralogues and is associated with 3 phenotypes. Biased expression in skin (RPKM 5.7), appendix (RPKM 0.9) and 1 other tissue.

Summary

The gene encodes a Lipase that is highly expressed in granular keratinocytes in the epidermis, and plays a role in the differentiation of keratinocytes. Mutations in this gene are associated with lamellar ichthyosis type 4. [provided by RefSeq, Dec 2011]

LIPN Products(1)

mRNA	Protein	Name
NM_001102469.2	NP_001095939.1	lipase member N precursor

LIPN Protein Structure

Abhydro_lipase

Abhydrolase_1

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

lipase member N

lipase-like abhydrolase domain-containing protein 4

Related Diseases

Diseases

Alias

Ichthyosis, Congenital, Autosomal Recessive 8

ARCI8	Autosomal Recessive Congenital Ichthyosis 8
Lamellar Ichthyosis 4	Late-Onset Lamellar Ichthyosis
Lamellar Ichthyosis, Late-Onset	Ichthyosis, Lamellar, 4, Formerly
Li4, Formerly	Li4
Ichthyosis, Congenital, Autosomal Recessive, Type 8

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Facial Nerve Disease

Facial Nerve Disorder	Facial Nerve Diseases
Neuropathy Of Facial Nerve	Disorders Of 7th Cranial Nerve
Disorders Of The Seventh Cranial Nerve

Bell'S Palsy

Bell Palsy	Facial Nerve Palsy
Facial Palsy	Facial Paralysis
Bell'S Palsy	Antoni'S Palsy
Facial Cranial Nerve Paralysis	Idiopathic Facial Palsy
Refrigeration Palsy	Facial Nerve Paralysis
Seventh Cranial Nerve Paralysis	Face Paralysis Nos

Facial Paralysis

Facial Palsy

Bell Palsy

Premenstrual Tension

Premenstrual Syndrome	Pmt - [Premenstrual Tension]
Premenstrual Tension Nos	Syndrome Of Menstruation

Epicondylitis

Tennis Elbow	Lateral Epicondylitis
Golfer'S Elbow	Medial Epicondylitis
Andrel Epicondylitis	Archer'S Elbow
Hockey Elbow	Shooter'S Elbow

Facial Neuralgia

Speech And Communication Disorders

Language Disorder	Communication Disorder
Language Disorders	Communication Disorders
Speech Language Disorder	Speech-Language Disorder
Communication Impairment	Speech And Language Disorder

Pain Agnosia

Analgesia

Brain Stem Infarction

Brain Stem Infarctions

Brainstem Infarction

Cerebellar Liponeurocytoma

Lipomatous Medulloblastoma

Central Neurocytoma

Ichthyosis, Congenital, Autosomal Recessive 7

ARCI7

Autosomal Recessive Congenital Ichthyosis 7

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Nerve Compression Syndrome

Entrapment Neuropathies	Compression Neuropathy
Entrapment Neuropathy	Peripheral Nerve Entrapment Syndrome
Nerve Compression Syndromes	Hereditary Liability To Pressure Palsies

Neurotic Disorder

Neurosis	Reactive Depression
Adjustment Disorders	Neurotic Disorders
Depressive Neurosis	Neurotic Depression
Neurotic Depression Reactive Type	Neurotic Depressive State
Psychoneurosis	Depressive Disorder
Depression, Neurotic

Myofascial Pain Syndrome

Myofascial Pain Syndromes	Myofascial Pain Dysfunction Syndrome
Fibromyalgia

Heel Spur

Calcaneal Spur

Ichthyosis, Congenital, Autosomal Recessive 4b

Harlequin Ichthyosis	Autosomal Recessive Congenital Ichthyosis 4b
Hi	Harlequin Fetus
ARCI4B	Ichthyosis Congenita, Harlequin Fetus Type
Harlequin Type Ichthyosis	'Harlequin Fetus'
Harlequin Type Ichthyosis Congenita	Harlequin Type Ichthyosis Fetalis
Harlequin Baby Syndrome	Ichthyosis Congenita, Harlequin Type
Ichthyosis Fetalis, Harlequin Type	Ichthyosis Congenita Harlequin Fetus Type
Ichthyosis, Harlequin	Ichthyosis, Congenital, Autosomal Recessive, Type 4b

Ichthyosis, Congenital, Autosomal Recessive 4a

Ichthyosis Congenita Iib	Icr2b
Autosomal Recessive Congenital Ichthyosis 4a	ARCI4A
Lamellar Ichthyosis 2	Li2
Ichthyosis, Lamellar, 2, Formerly	Li2, Formerly
Ichthyosis Lamellar 2	Lamellar Ichthyosis, Type 2
Ichthyosis, Lamellar 2	Ichthyosis, Congenital, Autosomal Recessive, Type 4a

Vertebrobasilar Insufficiency

Vertebro-Basilar Insufficiency	Vertebrobasilar Arterial Insufficiency
Vertebrobasilar Artery Syndrome

Spondylosis

Lumbar Spondylosis With Myelopathy	Lumbosacral Spondylosis Without Myelopathy
Spondylogenic Compression Of Lumbar Spinal Cord	Spondylogenic Compression Of Thoracic Spinal Cord
Spondylosis With Myelopathy	Thoracic Or Lumbar Spondylosis With Myelopathy

Trigeminal Nerve Disease

Trigeminal Nerve Diseases	Disorders Of 5th Cranial Nerve
Disorders Of The Fifth Cranial Nerve

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07695	LIPN Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LIPN	MGD	MGI:1917416
Rattus norvegicus	LIPN	RGD	RGD:1560354
Macaca mulatta	LIPN	VGNC	VGNC:74342
Felis catus	LIPN	VGNC	VGNC:63244
Bos taurus	LIPN	VGNC	VGNC:30909