BLVRB - biliverdin reductase B Gene

Also Known as FLR; BVRB; SDR43U1; HEL-S-10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 645

About BLVRB

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,447,768-40,465,745 (from NCBI)

This gene has 6 transcripts (splice variants) and 188 orthologues. Broad expression in bone marrow (RPKM 178.6), spleen (RPKM 63.9) and 23 other tissues.

Summary

The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase Enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]

BLVRB Products (1)

mRNA Protein Name
NM_000713.3 NP_000704.1 flavin reductase (NADPH)

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables biliverdin reductase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
7929092 GOA
enables peptidyl-cysteine S-nitrosylase activity IDA
IDA: Inferred from direct assay
38056462 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables riboflavin reductase (NADPH) activity IDA
IDA: Inferred from direct assay
11224564 GOA
enables riboflavin reductase (NADPH) activity IMP
IMP: Inferred from mutant phenotype
27207795 GOA
Biological Process GO Annotation Evidence References Source
involved in heme catabolic process IDA
IDA: Inferred from direct assay
7929092 GOA
involved in megakaryocyte differentiation IMP
IMP: Inferred from mutant phenotype
27207795 GOA
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
38056462 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
38056462 GOA
located in cytosol IDA
IDA: Inferred from direct assay
7929092 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BLVRB Protein Structure

NAD_binding_10

NAD_binding_10: NAD(P)H-binding (6 - 190)

  • 0
  • 100
  • 206 a.a.
Protein Preferred Names Protein Names

flavin reductase (NADPH)

  • BVR-B

BLVRB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BLVRB P30043 ANXA10 Homo sapiens Q9UJ72
Validated Y2H
32296183
Intra
BLVRB P30043 ANXA10 Homo sapiens Q9UJ72
Y2H Array
32296183
Intra
BLVRB P30043 ANXA10 Homo sapiens Q9UJ72
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BLVRB Proteins

Cat. No. Product Name Accession Purity
HY-P76172 BLVRB Protein, Human (His) P30043 (A2-Q206) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pyloric Stenosis
Achalasia

  • Cardiospasm

  • Achalasia Of Cardia

  • Esophageal Achalasia

  • Hypertensive Lower Esophageal Sphincter

  • Idiopathic Achalasia

  • Achalasia Cardia

  • Idiopathic Achalasia Of Esophagus

  • Primary Achalasia

  • Achalasia Of Esophagus

  • Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter

  • Aperistalsis Of The Oesophagus

  • Achalasia Of Oesophagus

  • Oesophageal Achalasia

  • Achalasia Nos

  • Cardia Spasm

  • Cardia Achalasia

  • Oesophageal Cardiospasm

  • Oesophagus Achalasia

  • Reflex Cardiospasm
Methemoglobinemia
Intestinal Atresia
Obstructive Jaundice

  • Jaundice, Obstructive

  • Cholestatic Jaundice

  • Cholestatic Jaundice Syndrome

  • Obstructive Hyperbilirubinemia

  • Jaundice Obstructive

  • Jaundice Cholestatic
Immunoglobulin Heavy-And-Light Chain

  • Ah/Al Amyloidosis

  • Ig Heavy-And-Light-Chain Amyloidosis
Megacolon

  • Dilatation Of Colon
Pulpitis

  • Pulp Stones

  • Pulpitis Nos
Intestinal Obstruction

  • Inspissated Milk Syndrome

  • Milk Curd Syndrome
Scrapie
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Alzheimer Disease, Familial, 1

  • Alzheimer Disease

  • Alzheimer'S Disease

  • Presenile And Senile Dementia

  • AD1

  • Alzheimer Disease, Susceptibility To

  • Alzheimer Disease, Late-Onset, Susceptibility To

  • Alzheimer Disease 1, Familial

  • AD

  • Familial Alzheimer Disease

  • Alzheimer Disease, Late-Onset

  • Alzheimers Dementia

  • Alzheimer Dementia

  • Alzheimer Sclerosis

  • Alzheimer Syndrome

  • Alzheimer-Type Dementia

  • Dat

  • Primary Senile Degenerative Dementia

  • Sdat

  • Alzheimer Disease 1

  • Autosomal Dominant Alzheimer Disease

  • Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

  • Late Onset Alzheimer Disease

  • Alzheimers Disease

  • Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

  • Late-Onset Alzheimers Disease

  • Alzheimer'S Disease Pathway Kegg

  • Dementia Due To Alzheimer'S Disease

  • Alzheimer Disease Type 1

  • Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01527 BLVRB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18649 Blvrb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25134 Blvrb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BLVRB RGD RGD:1306080
Mus musculus BLVRB MGD MGI:2385271
Macaca mulatta BLVRB VGNC VGNC:70257
Felis catus BLVRB VGNC VGNC:60126
Canis familiaris BLVRB VGNC VGNC:38472
Bos taurus BLVRB VGNC VGNC:26511
Others BLVRB NCBI