BLVRB - biliverdin reductase B Gene

Homo sapiens

Also known as FLR; BVRB; SDR43U1; HEL-S-10

Gene ID: 645 | Gene type: protein coding

About BLVRB

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,447,768-40,465,745 (from NCBI)

This gene has 6 transcripts (splice variants) and 188 orthologues. Broad expression in bone marrow (RPKM 178.6), spleen (RPKM 63.9) and 23 other tissues.

Summary

The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).[supplied by OMIM, Jul 2009]

BLVRB Products(1)

mRNA	Protein	Name
NM_000713.3	NP_000704.1	flavin reductase (NADPH)

BLVRB Protein Structure

NAD_binding_10

0
100
206 a.a.

Protein Preferred Names

Protein Names

flavin reductase (NADPH)

BVR-B

Recombinant BLVRB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76172	BLVRB Protein, Human (His)	P30043 (A2-Q206)	≥95%

Related Diseases

Diseases

Alias

Pyloric Stenosis

Achalasia

Cardiospasm	Achalasia Of Cardia
Esophageal Achalasia	Hypertensive Lower Esophageal Sphincter
Idiopathic Achalasia	Achalasia Cardia
Idiopathic Achalasia Of Esophagus	Primary Achalasia
Achalasia Of Esophagus	Lack Of Reflex Relaxation Of Lower Oesophageal Sphincter
Aperistalsis Of The Oesophagus	Achalasia Of Oesophagus
Oesophageal Achalasia	Achalasia Nos
Cardia Spasm	Cardia Achalasia
Oesophageal Cardiospasm	Oesophagus Achalasia
Reflex Cardiospasm

Methemoglobinemia

Intestinal Atresia

Obstructive Jaundice

Jaundice, Obstructive	Cholestatic Jaundice
Cholestatic Jaundice Syndrome	Obstructive Hyperbilirubinemia
Jaundice Obstructive	Jaundice Cholestatic

Immunoglobulin Heavy-And-Light Chain

Ah/Al Amyloidosis

Ig Heavy-And-Light-Chain Amyloidosis

Megacolon

Dilatation Of Colon

Pulpitis

Pulp Stones

Pulpitis Nos

Intestinal Obstruction

Inspissated Milk Syndrome

Milk Curd Syndrome

Scrapie

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01527	BLVRB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BLVRB	RGD	RGD:1306080
Mus musculus	BLVRB	MGD	MGI:2385271
Macaca mulatta	BLVRB	VGNC	VGNC:70257
Felis catus	BLVRB	VGNC	VGNC:60126
Canis familiaris	BLVRB	VGNC	VGNC:38472
Bos taurus	BLVRB	VGNC	VGNC:26511
Others	BLVRB	NCBI

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