Arl6ip5 - ADP-ribosylation factor-like 6 interacting protein 5 Gene

Also Known as Aip-5; addiscin; Gtrap3-18; 5930404D22Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 65106

Summary

Predicted to enable protein C-terminus binding activity. Involved in negative regulation of L-glutamate import across plasma membrane. Acts upstream of or within with a negative effect on L-glutamate import across plasma membrane and protein localization to plasma membrane. Acts upstream of or within several processes, including L-glutamate transmembrane transport; glutathione metabolic process; and neuron death in response to oxidative stress. Located in plasma membrane. Is expressed in cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human ARL6IP5 (ADP ribosylation factor like GTPase 6 interacting protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Arl6ip5 Products (1)

mRNA	Protein	Name
NM_022992.2	NP_075368.1	PRA1 family protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10508919	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within negative effect L-glutamate import across plasma membrane	IDA IDA: Inferred from direct assay	12119102	MGI
acts upstream of or within L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	12119102	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	12562531	MGI
acts upstream of or within cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	22210510	MGI
acts upstream of or within glutathione metabolic process	IMP IMP: Inferred from mutant phenotype	18799673	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	22210510	MGI
involved in negative regulation of L-glutamate import across plasma membrane	IDA IDA: Inferred from direct assay	18684713	MGI
acts upstream of or within negative effect protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	22210510	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in plasma membrane	IPI IPI: Inferred from physical interaction	18799673	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	17897781	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
PRA1 family protein 3	ADP-ribosylation factor-like protein 6-interacting protein 5 ADP-ribosylation-like factor 6 interacting protein 5 ARL-6-interacting protein 5 addicsin glutamate transporter EAAC1-interacting protein prenylated Rab acceptor protein 2 protein JWa

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00996	ARL6IP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arl6ip5	NCBI	NCBI:10550