Ppp5c - protein phosphatase 5, catalytic subunit Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 65179

Summary

Enables several functions, including G-protein alpha-subunit binding activity; microtubule binding activity; and protein serine/threonine Phosphatase activity. Involved in several processes, including histone dephosphorylation; positive regulation of Glucocorticoid Receptor signaling pathway; and response to arachidonic acid. Located in several cellular components, including cytosol; perikaryon; and proximal dendrite. Orthologous to human PPP5C (protein Phosphatase 5 catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ppp5c Products (1)

mRNA	Protein	Name
NM_031729.1	NP_113917.1	serine/threonine-protein phosphatase 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G-protein alpha-subunit binding	IDA IDA: Inferred from direct assay	12176367	RGD
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	8943293	RGD
enables microtubule binding	IDA IDA: Inferred from direct assay	14690518	RGD
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	8602837	RGD
enables phosphoprotein phosphatase activity	IMP IMP: Inferred from mutant phenotype	8077208	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12786973	RGD
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	15546861	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	2829978	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	12786973	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to cadmium ion	IEP IEP: Inferred from expression pattern	18703135	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	19038359	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19038359	RGD
involved in negative regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19686245	RGD
involved in positive regulation of glucocorticoid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8943293	RGD
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	8077208	RGD
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	16892053	RGD
involved in response to arachidonate	IDA IDA: Inferred from direct assay	15546861	RGD
involved in response to lead ion	IDA IDA: Inferred from direct assay	22387731	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	23134599	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in neuronal cell body	IDA IDA: Inferred from direct assay	12786973	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	16899232	RGD
located in proximal dendrite	IDA IDA: Inferred from direct assay	16899232	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
serine/threonine-protein phosphatase 5	PP5 PPT protein phosphatase T

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-171177	P5SA-2	Activator	99.51%	Unkown
HY-RS11032	PPP5C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp5c	NCBI	NCBI:5536