2. Gene
  3. Lima1 - LIM domain and actin binding 1 Gene

Lima1 - LIM domain and actin binding 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Eplin

Gene ID: 65970 | Gene type: protein coding

About Lima1

Summary

Enables actin filament binding activity. Involved in several processes, including Cholesterol homeostasis; intestinal Cholesterol absorption; and ruffle organization. Located in actin cytoskeleton; brush border membrane; and ruffle. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human LIMA1 (LIM domain and actin binding 1). [provided by Alliance of Genome Resources, Apr 2022]

Lima1 Products(2)

mRNA Protein Name
NM_001113545.2 NP_001107017.1 LIM domain and actin-binding protein 1 isoform a
NM_023063.5 NP_075550.2 LIM domain and actin-binding protein 1 isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables actin filament binding IMP
IMP: Inferred from mutant phenotype
17875928 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18093941 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
17875928 MGI
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
29880681 MGI
involved in intestinal cholesterol absorption IMP
IMP: Inferred from mutant phenotype
29880681 MGI
involved in ruffle organization IMP
IMP: Inferred from mutant phenotype
17875928 MGI
Cellular Component GO Annotation Evidence Reference Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
11179679 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in brush border membrane IDA
IDA: Inferred from direct assay
29880681 MGI
located in ruffle IDA
IDA: Inferred from direct assay
17875928 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

LIM domain and actin-binding protein 1

epithelial protein lost in neoplasm

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07657 LIMA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lima1 NCBI NCBI:51474