LIMA1 - LIM domain and actin binding 1 Gene

Also Known as EPLIN; LDLCQ8; SREBP3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51474

About LIMA1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:50,175,788-50,283,520 (from NCBI)

This gene has 16 transcripts (splice variants), 222 orthologues and is associated with 1 phenotype. Ubiquitous expression in colon (RPKM 57.9), small intestine (RPKM 51.2) and 23 other tissues.

Summary

This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some Cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

LIMA1 Products (12)

mRNA Protein Name
NM_001113546.2 NP_001107018.1 LIM domain and actin-binding protein 1 isoform 1
NM_001113547.2 NP_001107019.1 LIM domain and actin-binding protein 1 isoform 3
NM_001243775.2 NP_001230704.1 LIM domain and actin-binding protein 1 isoform 4
NM_001394886.1 NP_001381815.1 LIM domain and actin-binding protein 1 isoform 1
NM_001394887.1 NP_001381816.1 LIM domain and actin-binding protein 1 isoform 2
NM_001394888.1 NP_001381817.1 LIM domain and actin-binding protein 1 isoform 2
NM_001394889.1 NP_001381818.1 LIM domain and actin-binding protein 1 isoform 5
NM_001394890.1 NP_001381819.1 LIM domain and actin-binding protein 1 isoform 6
NM_001394891.1 NP_001381820.1 LIM domain and actin-binding protein 1 isoform 7
NM_001394892.1 NP_001381821.1 LIM domain and actin-binding protein 1 isoform 8
NM_001394893.1 NP_001381822.1 LIM domain and actin-binding protein 1 isoform 9
NM_016357.5 NP_057441.1 LIM domain and actin-binding protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
12566430 GOA
enables actin monomer binding IDA
IDA: Inferred from direct assay
12566430 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
Biological Process GO Annotation Evidence References Source
involved in actin filament bundle assembly IDA
IDA: Inferred from direct assay
12566430 GOA
involved in negative regulation of actin filament depolymerization IDA
IDA: Inferred from direct assay
12566430 GOA
involved in ruffle organization IDA
IDA: Inferred from direct assay
12566430 GOA
Cellular Component GO Annotation Evidence References Source
located in cleavage furrow IDA
IDA: Inferred from direct assay
20309963 GOA
located in focal adhesion IDA
IDA: Inferred from direct assay
10618726 GOA
located in stress fiber IDA
IDA: Inferred from direct assay
10618726 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIMA1 Protein Structure

LIM

LIM: LIM domain (390 - 445)

  • 0
  • 200
  • 400
  • 600
  • 759 a.a.
Protein Preferred Names Protein Names

LIM domain and actin-binding protein 1

  • epithelial protein lost in neoplasm beta

LIMA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LIMA1 Q9UHB6 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
LIMA1 Q9UHB6 DAPK1 Homo sapiens P53355
Protein Array
29513927
Intra
LIMA1 Q9UHB6 CTNNA1 Homo sapiens P35221
Anti Bait CoIP
18093941
Intra
LIMA1 Q9UHB6 CDH1 Homo sapiens P12830
Anti Bait CoIP
18093941
Cross
LIMA1 Q9UHB6 SVIL Bos taurus O46385
Y2H
20309963
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Low Density Lipoprotein Cholesterol Level Quantitative Trait Locus 8

  • LDLCQ8

  • Low Density Lipoprotein Cholesterol Level Qtl 8
Retinitis Pigmentosa 54

  • RP54

  • Retinitis Pigmentosa, Type 54
Chromosome 1p36 Deletion Syndrome

  • 1p36 Deletion Syndrome

  • Deletion 1p36

  • Monosomy 1p36

  • Subtelomeric 1p36 Deletion

  • Monosomy 1p36 Syndrome

  • Distal Monosomy 1p36

  • Del(1)(P36)

  • Deletion 1pter

  • Monosomy 1pter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07657 LIMA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LIMA1 RGD RGD:1564050
Bos taurus LIMA1 VGNC VGNC:30886
Mus musculus LIMA1 MGD MGI:1920992
Macaca mulatta LIMA1 VGNC VGNC:74114
Felis catus LIMA1 VGNC VGNC:63228
Canis familiaris LIMA1 VGNC VGNC:42677
Others LIMA1 NCBI