Aqp11 - aquaporin 11 Gene

Also Known as sjds; 1700015P13Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 66333

Summary

Enables water channel activity. Involved in several processes, including cellular water homeostasis; negative regulation of ERAD pathway; and oxygen homeostasis. Acts upstream of or within endosomal lumen acidification; proximal tubule development; and water transport. Located in endoplasmic reticulum; perinuclear region of cytoplasm; and plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and immune system. Orthologous to human AQP11 (Aquaporin 11). [provided by Alliance of Genome Resources, Apr 2022]

Aqp11 Products (1)

mRNA	Protein	Name
NM_175105.3	NP_780314.1	aquaporin-11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables water channel activity	IDA IDA: Inferred from direct assay	17178102	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within endosomal lumen acidification	IMP IMP: Inferred from mutant phenotype	16107722	MGI
involved in intracellular oxygen homeostasis	IMP IMP: Inferred from mutant phenotype	30656220	MGI
involved in intracellular water homeostasis	IDA IDA: Inferred from direct assay	21118806	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	16107722	MGI
involved in negative regulation of ERAD pathway	IMP IMP: Inferred from mutant phenotype	18606867	MGI
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	27582095	MGI
involved in negative regulation of response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	18606867	MGI
acts upstream of or within positive effect protein glycosylation	IMP IMP: Inferred from mutant phenotype	24854278	MGI
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	21118806	MGI
involved in protein targeting to membrane	IMP IMP: Inferred from mutant phenotype	24854278	MGI
acts upstream of or within proximal tubule development	IMP IMP: Inferred from mutant phenotype	18701606	MGI
involved in proximal tubule development	IMP IMP: Inferred from mutant phenotype	27582095	MGI
acts upstream of or within water transport	IDA IDA: Inferred from direct assay	17178102	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16107722	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16107722	MGI
located in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	24854278	MGI
NOT located in plasma membrane	IDA IDA: Inferred from direct assay	16107722	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	21118806	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
aquaporin-11	AQP-11 CG12251 gene product

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110200	TC AQP1 1	Inhibitor	98.03%	Unkown
HY-RS00873	AQP11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aqp11	NCBI	NCBI:282679