Skor2 - SKI family transcriptional corepressor 2 Gene

Also Known as Corl2; Gm7348; EG664805; Fussel18

Species: Mus musculus

Gene Type: protein coding

Gene ID: 664805

Summary

Enables SMAD binding activity; chromatin binding activity; and histone deacetylase binding activity. Acts upstream of or within several processes, including cerebellar Purkinje cell differentiation; regulation of dendrite morphogenesis; and regulation of signal transduction. Located in nucleus. Is expressed in brain; dorsal root ganglion; and spinal cord. Orthologous to human SKOR2 (SKI family transcriptional corepressor 2). [provided by Alliance of Genome Resources, Apr 2022]

Skor2 Products (1)

mRNA	Protein	Name
NM_001109743.1	NP_001103213.1	SKI family transcriptional corepressor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SMAD binding	IPI IPI: Inferred from physical interaction	21937600	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	24491816	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	21937600	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	24491816	MGI
acts upstream of or within cerebellar Purkinje cell differentiation	IMP IMP: Inferred from mutant phenotype	21937600	MGI
acts upstream of or within cerebellum morphogenesis	IMP IMP: Inferred from mutant phenotype	21937600	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	21937600	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21937600	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18522874	MGI
NOT acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	21937600	MGI
acts upstream of or within positive regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	21937600	MGI
acts upstream of or within regulation of cerebellar granule cell precursor proliferation	IMP IMP: Inferred from mutant phenotype	21937600	MGI
acts upstream of or within regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	21937600	MGI
acts upstream of or within regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	21937600	MGI
acts upstream of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	21937600	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	18522874	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
SKI family transcriptional corepressor 2	LBX1 corepressor 1-like protein functional Smad suppressor element on chromosome 18 fussel-18 homolog ladybird homeobox corepressor 1-like protein transcriptional corepressor Corl2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12972	SKOR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Skor2	NCBI	NCBI:652991