SKOR2 - SKI family transcriptional corepressor 2 Gene

Also Known as CORL2; CH18515; FUSSEL18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 652991

About SKOR2

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:47,206,169-47,251,660 (from NCBI)

This gene has 3 transcripts (splice variants), 180 orthologues and 3 paralogues. Low expression observed in reference dataset.

Summary

Enables SMAD binding activity and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SKOR2 Products (2)

mRNA Protein Name
NM_001037802.3 NP_001032891.1 SKI family transcriptional corepressor 2 isoform 2
NM_001278063.4 NP_001264992.1 SKI family transcriptional corepressor 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SMAD binding IPI
IPI: Inferred from physical interaction
16200078 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
16200078 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16200078 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16200078 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SKOR2 Protein Structure

Ski_Sno

Ski_Sno: SKI/SNO/DAC family (22 - 132)

c-SKI_SMAD_bind

c-SKI_SMAD_bind: c-SKI Smad4 binding domain (144 - 236)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1001 a.a.
Protein Preferred Names Protein Names

SKI family transcriptional corepressor 2

  • LBX1 corepressor 1-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12972 SKOR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SKOR2 VGNC VGNC:107724
Bos taurus SKOR2 VGNC VGNC:56373
Rattus norvegicus SKOR2 RGD RGD:1598071
Macaca mulatta SKOR2 VGNC VGNC:104247
Mus musculus SKOR2 MGD MGI:3645984
Others SKOR2 NCBI