2. Gene
  3. Sppl2a - signal peptide peptidase like 2A Gene

Sppl2a - signal peptide peptidase like 2A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 2010106G01Rik; C130089K23Rik

Gene ID: 66552 | Gene type: protein coding

About Sppl2a

Summary

Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to act upstream of or within proteolysis. Located in late endosome membrane and lysosomal membrane. Is expressed in genitourinary system; skeleton; and thymus primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human SPPL2A (signal peptide peptidase like 2A). [provided by Alliance of Genome Resources, Apr 2022]

Sppl2a Products(1)

mRNA Protein Name
NM_023220.2 NP_075709.2 signal peptide peptidase-like 2A precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in membrane protein proteolysis IMP
IMP: Inferred from mutant phenotype
33239420 MGI
involved in regulation of immune response IMP
IMP: Inferred from mutant phenotype
30127434 MGI
Cellular Component GO Annotation Evidence Reference Source
located in late endosome membrane IDA
IDA: Inferred from direct assay
21896273 MGI
located in lysosomal membrane IDA
IDA: Inferred from direct assay
21896273 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

signal peptide peptidase-like 2A

IMP-3

SPP-like 2A protein

intramembrane protease 3

presenilin-like protein 2

protein SPPL2a

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111360 SPL-707 Inhibitor 99.64% Unkown
HY-128356 SPL-410 Inhibitor 99.38% Unkown
HY-RS13704 SPPL2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sppl2a NCBI NCBI:84888